Evidence map›Paper›PMID 31814875›Full record

ArticleOxidative medicine and cellular longevity2019

Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway.

You-Cheng Hseu, Chih-Ting Chang, Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen, Hui-Chang Lin, Hung-Rong Yen, Hsin-Ling Yang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Turkish journal of biology = Turk biyoloji dergisi · 2025
    Article
  4. Review
  5. Review
  6. Protective Mechanism ofAntioxidants (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Anti-Photoaging Effect ofNutrients · 2022
    Article
  18. Article
  19. Article
  20. Role of Phytochemicals in Skin PhotoprotectionFrontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

You-Cheng HseuDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0001-5307-6162
Chih-Ting ChangDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
Yugandhar Vudhya GowrisankarDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
Xuan-Zao ChenDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
Hui-Chang LinSchool of Pharmacy, China Medical University, Taichung 40402, Taiwan.
Hung-Rong YenChinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0002-0131-1658
Hsin-Ling YangInstitute of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0002-3561-7372
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultraviolet A (UVA) irradiation (320-400 nm range) triggers deleterious consequences in skin cell microenvironment leading to skin damage, photoaging (premature skin aging), and cancer. The accumulation of intracellular reactive oxygen species (ROS) plays a key role in this effect. With rapid progress in cosmetic health and quality of life, use of safe and highly effective phytochemicals has become a need of the hour. Zerumbone (ZER), a natural sesquiterpene, from

Indexed as

FibroblastsHumansNF-E2-Related Factor 2Reactive Oxygen SpeciesSesquiterpenesSkinTransfectionUltraviolet RaysUltraviolet TherapyNFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesSesquiterpeneszerumbone

Identifiers

PMID31814875
PMCPMC6878809
OpenAlexW2987555622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.