Evidence map›Paper›PMID 31814858›Full record

ArticleDisease markers2019

Altered Levels of mRNAs for Calcium-Binding/Associated Proteins, Annexin A1, S100A4, and TMEM64, in Peripheral Blood Mononuclear Cells Are Associated with Osteoporosis.

Ayed A Dera, Lakshminarayan Ranganath, Roger Barraclough, Sobhan Vinjamuri, Sandra Hamill, Abdullah Y Mandourah, Dong L Barraclough

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. CD4Combinatorial chemistry & high throughput screening · 2026
    Article
  2. Article
  3. Bioinformatics analysis identification ofExperimental and therapeutic medicine · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ayed A DeraDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, The William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.
Lakshminarayan RanganathDepartment of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospital NHS Trust, Prescot Street, Liverpool L7 8XP, UK.
Roger BarracloughDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK.
Sobhan VinjamuriDepartment of Nuclear Medicine, The Royal Liverpool and Broadgreen University Hospital NHS Trust, Prescot Street, Liverpool L7 8XP, UK.
Sandra HamillDepartment of Nuclear Medicine, The Royal Liverpool and Broadgreen University Hospital NHS Trust, Prescot Street, Liverpool L7 8XP, UK.
Abdullah Y MandourahDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, The William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.
Dong L BarracloughDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, The William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.ORCID https://orcid.org/0000-0001-8440-0623
University of Liverpool · GBRoyal Liverpool and Broadgreen University Hospital NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporosis is the most common metabolic bone disease in the world. Since osteoporosis is clinically symptomless until the first fracture occurs, early diagnosis is critical. Calcium, along with calcium-binding and calcium-associated proteins, plays an important role in homeostasis, maintaining healthy bone metabolism. This study is aimed at investigating the level of calcium-binding/associated proteins, annexin A1, S100A4, and TMEM64, in peripheral blood mononuclear cells associated with osteoporosis and its clinical significance.

methodsThe levels of mRNAs of annexin A1, S100A4, and TMEM64 in human peripheral blood mononuclear cells were evaluated among 48 osteopenia and 23 osteoporosis patients compared to 17 nonosteoporotic controls. Total RNAs were isolated from clinical samples, and quantitation of mRNA levels was performed using real-time quantitative PCR.

resultsThe levels of mRNAs for calcium-binding proteins, annexin A1 and S100A4, and calcium-associated protein, TMEM64, in human peripheral blood mononuclear cells were significantly reduced in osteopenia and osteoporosis patients compared with nonosteoporotic controls (one-way ANOVA,

conclusionsThe results show for the first time that calcium-binding/associated proteins, annexin A1 and TMEM64, could be future diagnostic biomarkers for osteoporosis.

Indexed as

Annexin A1BiomarkersBone Diseases, MetabolicCase-Control StudiesFemaleFollow-Up StudiesHumansLeukocytes, MononuclearMaleMembrane ProteinsMiddle AgedOsteoporosisPrognosisRNA, MessengerS100 Calcium-Binding Protein A4Annexin A1ANXA1 protein, humanBiomarkersMembrane ProteinsRNA, MessengerS100A4 protein, humanS100 Calcium-Binding Protein A4

Identifiers

PMID31814858
PMCPMC6877971
OpenAlexW2989077843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.