Evidence map›Paper›PMID 31814628›Full record

ArticleAutomatica : the journal of IFAC, the International Federation of Automatic Control2019

Estimating the Distribution of Random Parameters in a Diffusion Equation Forward Model for a Transdermal Alcohol Biosensor.

Melike Sirlanci, Susan E Luczak, Catharine E Fairbairn, Dahyeon Kang, Ruoxi Pan, Xin Yu, I G Rosen

Registry-linked trialAbstract read
In one paragraph

Article in Automatica : the journal of IFAC, the International Federation of Automatic Control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692830 (Towards a Wearable Alcohol Biosensor), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05692830 recruitingnot on this mapstarted 2022, after this paper: background citation

Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms

TypeobservationalSponsorUniversity of Illinois at Urbana-ChampaignRan2022 to 2027Enrolled240ConditionsAlcohol Drinking, Alcohol IntoxicationArmsAlcohol
3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melike SirlanciModeling and Simulation Laboratory, Department of Mathematics, University of Southern California, sirlanci@usc.edu, grosen@math.usc.edu.
Susan E LuczakDepartment of Psychology, University of Southern California, luczak@usc.edu.
Catharine E FairbairnDepartment of Psychology, University of Illinois, cfairbai@illinois.edu, dkang38@illinois.edu.
Dahyeon KangDepartment of Psychology, University of Illinois, cfairbai@illinois.edu, dkang38@illinois.edu.
Ruoxi PanDepartment of Mathematics, University of Southern California (undergraduate student).
Xin YuDepartment of Mathematics, University of Southern California (undergraduate student).
I G RosenModeling and Simulation Laboratory, Department of Mathematics, University of Southern California, sirlanci@usc.edu, grosen@math.usc.edu.

Funding

Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory MethodsR01AA025969 · NIAAA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Catharine Fairbairn · 2017 to 2026
$3.5M
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor DataR01AA026368 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUCZAK, SUSAN E, ROSEN, GARY · 2018 to 2022
$2.8M
Real-Time Assessment of Alcohol Use Across ALDH2 GenotypesR21AA017711 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUCZAK, SUSAN E · 2009 to 2010
$410k
NIAAA NIH HHS R01 AA025969NIAAA NIH HHS R01 AA026368NIAAA NIH HHS R21 AA017711
6 · The paper itself

Abstract

We estimate the distribution of random parameters in a distributed parameter model with unbounded input and output for the transdermal transport of ethanol in humans. The model takes the form of a diffusion equation with the input being the blood alcohol concentration and the output being the transdermal alcohol concentration. Our approach is based on the idea of reformulating the underlying dynamical system in such a way that the random parameters are now treated as additional space variables. When the distribution to be estimated is assumed to be defined in terms of a joint density, estimating the distribution is equivalent to estimating the diffusivity in a multi-dimensional diffusion equation and thus well-established finite dimensional approximation schemes, functional analytic based convergence arguments, optimization techniques, and computational methods may all be employed. We use our technique to estimate a bivariate normal distribution based on data for multiple drinking episodes from a single subject.

Indexed as

Biosensor dataBlood alcohol concentrationDistributed parameter systemsDistribution estimationRandom parametersTransdermal alcohol concentration

Identifiers

PMID31814628
PMCPMC6897358

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.