Evidence map›Paper›PMID 31814311›Full record

ArticleProteomics2020

Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens.

Hyung W Nam, Caleb A Grant, Ashton N Jorgensen, Carrie J Holtz-Heppelmann, Marjan Trutschl, Urska Cvek

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hyung W NamDepartment of Pharmacology, Toxicology, and Neuroscience, Health Science Center, Louisiana State University, Shreveport, LA, 71130, USA.ORCID 0000-0002-8294-7403
Caleb A GrantDepartment of Pharmacology, Toxicology, and Neuroscience, Health Science Center, Louisiana State University, Shreveport, LA, 71130, USA.
Ashton N JorgensenDepartment of Pharmacology, Toxicology, and Neuroscience, Health Science Center, Louisiana State University, Shreveport, LA, 71130, USA.
Carrie J Holtz-HeppelmannMedical Genome Facility, Mayo Clinic, Rochester, MN, 55905, USA.
Marjan TrutschlDepartment of Computer Science, Louisiana State University-Shreveport, Shreveport, LA, 71115, USA.
Urska CvekDepartment of Computer Science, Louisiana State University-Shreveport, Shreveport, LA, 71115, USA.
Louisiana State University · USLouisiana State University in Shreveport · USMayo Clinic · US

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
NIGMS NIH HHS 121307NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

Dysfunction of glutamate neurotransmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng) is exclusively expressed in the brain and mediates N-methyl-d-aspartate receptor (NMDAR) hypo-function by regulating the intracellular calcium-calmodulin (Ca

Indexed as

AnimalsCentral Nervous System DepressantsChromatography, LiquidEthanolgamma-Aminobutyric AcidGenotypeGlutamic AcidMaleMice, KnockoutMicrodialysisNeurograninNucleus AccumbensProteomeProteomicsProto-Oncogene Proteins c-aktSignal TransductionCentral Nervous System DepressantsEthanolgamma-Aminobutyric AcidGlutamic AcidNeurograninProteomeProto-Oncogene Proteins c-aktalcoholismbioinformaticslabel-free proteomicsneurograninpharmacoproteomics

Identifiers

PMID31814311
PMCPMC7038789
OpenAlexW2992389532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.