Evidence map›Paper›PMID 31814310›Full record

ReviewThoracic cancer2020

Management of immune checkpoint inhibitor-related dermatologic adverse events.

Xiaoyan Si, Chunxia He, Li Zhang, Xiaowei Liu, Yue Li, Hanping Wang, Xiaoxiao Guo, Jiaxin Zhou, Lian Duan, Mengzhao Wang and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Thoracic cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaoyan SiDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.ORCID 0000-0003-2913-3045
Chunxia HeDepartment of Dermatology, Peking Union Medical College Hospital, Beijing, China.
Li ZhangDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Beijing, China.
Xiaowei LiuDepartment of Ophthalmology, Peking Union Medical College Hospital, Beijing, China.
Yue LiDepartment of Gastroenterology, Peking Union Medical College Hospital, Beijing, China.
Hanping WangDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.ORCID 0000-0003-3540-2280
Xiaoxiao GuoDepartment of Cardiology, Peking Union Medical College Hospital, Beijing, China.ORCID 0000-0002-8583-5992
Jiaxin ZhouDepartment of Rheumatology, Peking Union Medical College Hospital, Beijing, China.ORCID 0000-0002-1664-3495
Lian DuanDepartment of Endocrinology, Peking Union Medical College Hospital, Beijing, China.
Mengzhao WangDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.
Li ZhangDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

CAMS Innovation Fund for Medical Sciences 2016-I2M-1-002
6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The unique spectrum of immune-related adverse events (IrAEs) may occur during treatment. Dermatologic toxicities appear to be one of the most prevalent immunotherapy-related adverse events. The most common symptoms are maculopapular rash and pruritus. Serious dermatologic toxicities including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms are rare. In this review, we summarize guidelines of management of immunotherapy-related toxicities, case reports, and proposed treatment recommendation.

Indexed as

Drug-Related Side Effects and Adverse ReactionsHumansImmune Checkpoint InhibitorsNeoplasmsPractice Guidelines as TopicPrognosisSkin DiseasesImmune Checkpoint InhibitorsDermatologic toxicitiesimmune checkpoint inhibitor (ICI)immune-related adverse events (IrAEs)

Identifiers

PMID31814310
PMCPMC6997012
OpenAlexW2991436208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.