Evidence map›Paper›PMID 31814258›Full record

ArticleJournal of applied microbiology2020

Prevention of excessive exercise-induced adverse effects in rats with Bacillus subtilis BSB3.

H A G Ducray, L Globa, O Pustovyy, M D Roberts, M Rudisill, V Vodyanoy, I Sorokulova

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Effects of a multi-strainTranslational animal science · 2022
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

H A G DucrayDepartment of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA.
L GlobaDepartment of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA.
O PustovyyDepartment of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA.
M D RobertsSchool of Kinesiology, Auburn University, Auburn, AL, USA.
M RudisillSchool of Kinesiology, Auburn University, Auburn, AL, USA.
V VodyanoyDepartment of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA.
I SorokulovaDepartment of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA.ORCID https://orcid.org/0000-0002-5862-8525
Auburn University · US

Funding

Auburn University
6 · The paper itself

Abstract

aimsTo characterize efficacy of the Bacillus subtilis BSB3 (BSB3) strain in the prevention of excessive exercise-induced side effects and in maintaining stability of the gut microbiota. METHODS AND

resultsRats were pretreated by oral gavage with B. subtilis BSB3 (BSB3) or with phosphate-buffered saline (PBS) twice a day for 2 days, and were either exposed forced treadmill running or remained sedentary. Histological analysis of intestine, immunofluorescence staining of tight junction (TJ) proteins, serum lipopolysaccharide and intestinal fatty acid-binding protein assay, culture-based analysis and pyrosequencing for the gut microbiota were performed for each rat. Forced running resulted in a substantial decrease in intestinal villi height and total mucosa thickness, the depletion of Paneth cells, an inhibition of TJ proteins expression. Short-term treatment of rats with BSB3 before running prevented these adverse effects. Culture-based analysis of the gut microbiota revealed significant elevation of pathogenic microorganisms only in treadmill-exercised rats pretreated with PBS. High-throughput 16S rRNA gene sequencing also revealed an increase in pathobionts in this group. Preventive treatment of animals with BSB3 resulted in predominance of beneficial bacteria.

conclusionsBSB3 prevents excessive exercise-associated complications by beneficial modulation of the gut microbiota. SIGNIFICANCE AND IMPACT OF THE STUDY: Our study shows a new application of beneficial bacteria for prevention the adverse effects of excessive exercise.

Indexed as

ProbioticsAdministration, OralAnimalsBacillus subtilisGastrointestinal MicrobiomeIntestinal MucosaLipopolysaccharidesMalePhysical Conditioning, AnimalRatsLipopolysaccharidesBacillus subtilisgut microbiotaI-FABPLPSside effects of excessive exercisetight junction proteins

Identifiers

PMID31814258
PMCPMC7079029
OpenAlexW2993151688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.