ArticleCancer2020
Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan.
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of self-report measures used in epidemiological studies to assess alcohol consumption among older adults.PloS one · 2021Pooled it
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- Occupational Disparities in Cancer Survival Among the Working Population in Japan: 10-Year Survival Analysis Using the Kanagawa Cancer Registry.Cancer medicine · 2025Observational
- Association among occupational class, alcohol consumption, and the risk of hospitalisations due to alcoholic liver diseases: a matched case-control study.BMC public health · 2025Article
- Association between Tooth Extraction 2 Weeks before Radiotherapy and Osteoradionecrosis in Patients with Advanced Oral and Oropharyngeal Cancer.Journal of Cancer · 2025Article
- Association between ocular diseases and screen time and sedentary time derived from job-exposure matrices.Scientific reports · 2024Article
- Decreased antioxidant-related superoxide dismutase 1 expression in peripheral immune cells indicates early ethanol exposure.Scientific reports · 2024Article
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- Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy.International journal of clinical oncology · 2024Article
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- Alcohol use patterns and risk of incident cataract surgery: a large scale case-control study in Japan.Scientific reports · 2022Article
- Association Between Changes in Alcohol Consumption and Cancer Risk.JAMA network open · 2022Article
- A prospective cohort study of cigarette smoking, alcohol drinking and liver cancer incidence in Chinese men.Journal of digestive diseases · 2022Article
- The effects of modest drinking on life expectancy and mortality risks: a population-based cohort study.Scientific reports · 2022Article
- Lower urinary tract symptoms and functional ability in older adults: a community-based cross-sectional study.BMJ open · 2022Article
- A risk factor for newly diagnosed secondary cancer in patients with early-stage laryngeal, oropharyngeal, or hypopharyngeal cancer: sub-analysis of a prospective observation study.International journal of clinical oncology · 2022Article
- Alcohol and Prostate Cancer: Time to Draw Conclusions.Biomolecules · 2022Review
- Dietary change in high-income nations alone can lead to substantial double climate dividend.Nature food · 2022Article
- Dairy products and the risk of developing prostate cancer: A large-scale cohort study (JACC Study) in Japan.Cancer medicine · 2021Article
- Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium.Journal of epidemiology and community health · 2021Article
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEven light to moderate alcohol consumption has been shown to increase cancer incidence. However, this association has not been well characterized in Japan.
methodsBased on a nationwide, hospital-based data set (2005-2016), a multicenter case-control study was conducted (63,232 cancer cases and 63,232 controls matched for sex, age, admission date, and admitting hospital). The total amount of lifetime alcohol consumption (drink-years) was recalled for each patient by multiplication of the daily amount of standardized alcohol use (drinks per day) and the duration of drinking (years). Odds ratios (ORs) were estimated for overall and specific cancer sites via conditional logistic regression with restricted cubic splines, with adjustments made for smoking, occupational class, and comorbidities. Lifetime abstainers served as the reference group.
resultsSpline curves showed a dose-response association with overall cancer risk: the minimum risk was at 0 drink-years, and the OR at 10 drink-years was 1.05 (95% confidence interval [CI], 1.04-1.06). In comparison with lifetime abstainers, the OR for >0 to 20 drink-years was 1.06 (95% CI, 1.01-1.11). Those who drank 2 drinks or fewer per day had elevated odds for overall cancer risk across all duration-of-drinking categories. The same patterns were observed at light to moderate levels of drinking for most gastrointestinal/aerodigestive cancers as well as breast and prostate cancers. Analyses stratified by sex, different drinking/smoking behaviors, and occupational class mostly showed the same patterns for overall cancer incidence associated with light to moderate levels of drinking.
conclusionsIn Japan, even light to moderate alcohol consumption appears to be associated with elevated cancer risks.
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