Evidence map›Paper›PMID 31814058›Full record

SynthesisNeurosurgical review2021

Safety and efficacy of magnetic resonance imaging-guided focused ultrasound neurosurgery for Parkinson's disease: a systematic review.

Yangyang Xu, Qi He, Mengqi Wang, Yuan Gao, Xiaowei Liu, Denghui Li, Botao Xiong, Wei Wang

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Parkinson's disease therapy: what lies ahead?Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Tremor in Parkinson's Disease: From Pathophysiology to Advanced Therapies.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022
    Review
  12. Article
  13. Novel targeted therapies for Parkinson's disease.Molecular medicine (Cambridge, Mass.) · 2021
    Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yangyang Xu *Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Qi He *Department of Neonatology, West China Second University Hospital Sichuan University, Chengdu, 610041, China.
Mengqi WangDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Yuan GaoDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Xiaowei LiuDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Denghui LiDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Botao XiongDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Wei WangDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 610041, China. wcnsww@163.com.ORCID http://orcid.org/0000-0002-3110-5767

Funding

135 Project of Outstanding Development of West China Hospital ZY2017307National Natural Science Foundation of China 81870999
6 · The paper itself

Abstract

Magnetic resonance imaging-guided focused ultrasound (MRgFUS) neurosurgery is a new option for medication-resistant Parkinson's disease (PD), but its safety and efficacy remain elusive. This study aimed to investigate the safety and efficacy of MRgFUS for PD by systematically reviewing related literature. PubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the efficacy or safety of MRgFUS for PD and (2) published in English. Exclusion criteria were (1) nonhuman study, (2) review or meta-analysis or other literature types without original data, and (3) conference abstract without full text. Data on study characteristics, treatment parameters, efficacy, and adverse events were collected. Descriptive synthesis of data was performed. Eleven studies containing 80 patients were included. Nine studies were observational studies with no controls. Two studies included a randomized and controlled phase. Most studies included tremor-dominant PD. Ten studies reported decline of UPDRS-III scores after MRgFUS, and five reported a statistically significant decline. Nine studies evaluated the quality of life (QOL). Significant improvement of QOL was reported by four studies using the 39-item Parkinson's disease questionnaire. Four studies investigated the impact of MRgFUS on non-motor symptoms. Most tests indicated that MRgFUS had no significant effect on neuropsychological outcomes. Most adverse events were mild and transient. MRgFUS is a potential treatment for PD with satisfying efficacy and safety. Studies in this field are still limited. More studies with strict design, larger sample size, and longer follow-up are needed to further investigate its efficacy and safety for PD.

Indexed as

HumansMagnetic Resonance ImagingNeurosurgical ProceduresParkinson DiseaseRandomized Controlled Trials as TopicSurgery, Computer-AssistedTreatment OutcomeUltrasonographyEfficacyMagnetic resonance imaging-guided focused ultrasoundParkinson’s diseaseSafetySystematic review

Identifiers

PMID31814058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.