ArticleCerebral cortex (New York, N.Y. : 1991)2020
Sex-Based Differences in Cortical and Subcortical Development in 436 Individuals Aged 4-54 Years.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- A comparative assessment of age- and gender-related variations in brain morphometry using linear and volumetric MRI analysis.BMC medical imaging · 2026Article
- Benchmarking Multimodal Deep Fusion Strategies for Heterogeneous Neuroimaging and Cognitive Data Using a Controlled Sex Classification Task.Brain sciences · 2026Article
- Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.Journal of Alzheimer's disease : JAD · 2026Article
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health.Communications biology · 2025Article
- A FastSurfer Database for Age-Specific Brain Volumes in Healthy Children: A Tool for Quantifying Localized and Global Brain Volume Alterations in Pediatric Patients.Brain and behavior · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- First establishment of population-specific brain volume reference standards for Chinese children and adolescents: an AI-based segmentation study.Frontiers in pediatrics · 2025Article
- Leveraging the adolescent brain cognitive development study to improve behavioral prediction from neuroimaging in smaller replication samples.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats.Frontiers in endocrinology · 2024Article
- Long-term consequences of neonatal encephalopathy in the hypothermia era: protocol for a follow-up cohort study at 9 years of age.BMJ open · 2023Article
- Postnatal maternal distress, infant subcortical brain macrostructure and emotional regulation.Psychiatry research. Neuroimaging · 2023Article
- Virtual Ontogeny of Cortical Growth Preceding Mental Illness.Biological psychiatry · 2022Article
- Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain.Brain structure & function · 2022Article
- Academic achievements and brain volume development in children and adolescents.Cerebral cortex communications · 2022Article
- Investigating sexual dimorphism in human brain structure by combining multiple indexes of brain morphology and source-based morphometry.Brain structure & function · 2022Article
- Mapping Progressive Gray Matter Alterations in Early Childhood Autistic Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Altering Cell-Cell Interaction in Prenatal Alcohol Exposure Models: Insight on Cell-Adhesion Molecules During Brain Development.Frontiers in molecular neuroscience · 2021Review
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4 authors.
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Abstract
Sex-based differences in brain development have long been established in ex vivo studies. Recent in vivo studies using magnetic resonance imaging (MRI) have offered considerable insight into sex-based variations in brain maturation. However, reports of sex-based differences in cortical volumes and thickness are inconsistent. We examined brain maturation in a cross-sectional, single-site cohort of 436 individuals (201 [46%] males) aged 4-54 years (median = 16 years). Cortical thickness, cortical surface area, subcortical surface area, volumes of the cerebral cortex, white matter (WM), cortical and subcortical gray matter (GM), including the thalamic subnuclei, basal ganglia, and hippocampi were calculated using automatic segmentation pipelines. Subcortical structures demonstrated distinct curvilinear trajectories from the cortex, in both volumetric maturation and surface-area expansion in relation to age. Surface-area analysis indicated that dorsal regions of the thalamus, globus pallidus and striatum, regions demonstrating structural connectivity with frontoparietal cortices, exhibited extensive expansion with age, and were inversely related to changes seen in cortical maturation, which contracted with age. Furthermore, surface-area expansion was more robust in males in comparison to females. Age- and sex-related maturational changes may reflect alterations in dendritic and synaptic architecture known to occur during development from early childhood through to mid-adulthood.
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