Evidence map›Paper›PMID 31813983›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020

Noncardiac-Related Morbidity, Mobility Limitation, and Outcomes in Older Adults With Heart Failure.

Mayra Tisminetzky, Jerry H Gurwitz, Dongjie Fan, Kristi Reynolds, David H Smith, Hassan Fouayzi, Sue Hee Sung, Robert Goldberg, Alan S Go

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mayra TisminetzkyMeyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.
Jerry H GurwitzMeyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.
Dongjie FanDivision of Research, Kaiser Permanente Northern California, Oakland.
Kristi ReynoldsDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
David H SmithCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Hassan FouayziMeyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.
Sue Hee SungDivision of Research, Kaiser Permanente Northern California, Oakland.
Robert GoldbergMeyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.
Alan S GoDivision of Research, Kaiser Permanente Northern California, Oakland.
Kaiser Permanente · USUniversity of Massachusetts Chan Medical School · USKaiser Permanente Center for Health Research · US

Funding

Preparing For What Is Next With Aducanumab In Real World SettingsR33AG057806 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Christopher Barrett Bowling, Ana Roman Quinones · 2018 to 2026
$9.0M
HMO Research Network Cardiovascular Research NetworkU19HL091179 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2007 to 2011
$8.7M
Advancing Geriatrics Infrastructure & Network Growth - Admin Supplement: Designing and Testing an Informatics Tool to Aid Prescribers in Reducing Anticholinergic Burden in Older AdultsR24AG045050 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GURWITZ, JERRY H · 2014 to 2017
$3.6M
Multimorbidity and Treatment-Related Outcomes in Older Heart Failure PatientsR01AG062630 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TISMINETZKY, MAYRA S. · 2019 to 2022
$2.4M
Management and Outcomes of Heart Failure with Preserved Systolic FunctionRC1HL099395 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2009 to 2010
$1000k
NHLBI NIH HHS RC1 HL099395NHLBI NIH HHS U19 HL091179NIA NIH HHS R01 AG062630NIA NIH HHS R24 AG045050NIA NIH HHS R33 AG057806
6 · The paper itself

Abstract

backgroundTo examine the individual and combined associations of noncardiac-related conditions and mobility limitation with morbidity and mortality in adults with heart failure (HF).

methodsWe conducted a retrospective cohort study in a large, diverse group of adults with HF from five U.S. integrated healthcare delivery systems. We characterized patients with respect to the presence of noncardiac conditions (<3 vs ≥3) and/or mobility impairment (defined by the use/nonuse of a wheelchair, cane, or walker), categorizing them into four subgroups. Outcomes included all-cause death and hospitalizations for HF or any cause.

resultsAmong 114,553 adults diagnosed with HF (mean age: 73 years old, 46% women), compared with <3 noncardiac conditions/no mobility limitation, adjusted hazard ratios (HR) for all-cause death among those with <3 noncardiac conditions/mobility limitation, ≥3 noncardiac conditions/no mobility limitation, ≥3 noncardiac conditions/mobility limitation (vs) were 1.40 (95% CI, 1.31-1.51), 1.72 (95% CI, 1.69-1.75), and 1.93 (95% CI, 1.85-2.01), respectively. We did not observe an increased risk of any-cause or HF-related hospitalization related to the presence of mobility limitation among those with a greater burden of noncardiac multimorbidity. Consistent findings regarding mortality were observed within groups defined according to age, gender, and HF type (preserved, reduced, mid-range ejection fraction), with the most prominent impact of mobility limitation in those <65 years of age.

conclusionsThere is an additive association of mobility limitation, beyond the burden of noncardiac multimorbidity, on mortality for patients with HF, and especially prominent in younger patients.

Indexed as

Mobility LimitationAgedAged, 80 and overFemaleHeart FailureHumansMaleMorbidityRetrospective StudiesRisk FactorsUnited StatesMobility impairmentMortalityMultimorbidity

Identifiers

PMID31813983
PMCPMC7518555
OpenAlexW2996362936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.