ArticleCerebral cortex (New York, N.Y. : 1991)2020
Pain-Evoked Reorganization in Functional Brain Networks.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed.
- Lower resting-state functional connectivity between frontoparietal and sensory networks is associated with recent pain intensity in a community sample of youth.Neuroimage. Reports · 2026Article
- Altered locus coeruleus functional connectivity in migraine without aura based on resting-state functional magnetic resonance imaging.Journal of oral & facial pain and headache · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Surgery-related factors associated with early postoperative kinesiophobia in geriatric hip fracture patients: a risk stratification model.Frontiers in medicine · 2026Article
- Distinct functional cerebral hypersensitivity networks during incisional and inflammatory pain in rats.Current research in neurobiology · 2025Article
- Multimodal Correspondence between Optogenetic fMRI, Electrophysiology, and Anatomical Maps of the Secondary Somatosensory Cortex in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.BMC medical imaging · 2025Article
- Neuroplasticity in chronic pain: insights into diagnosis and treatment.The Korean journal of pain · 2025Article
- Adverse childhood experiences, brain efficiency, and the development of pain symptoms in youth.European journal of pain (London, England) · 2025Article
- Reconfiguration of brain network dynamics in bipolar disorder: a hidden Markov model approach.Translational psychiatry · 2024Article
- A distributed brain response predicting the facial expression of acute nociceptive pain.eLife · 2024Article
- No sex difference in maturation of brain morphology during the perinatal period.Brain structure & function · 2024Article
- Article
- Individuals With Prior Chronic Pain and Long-Term Opioid Treatment May Experience Persistence of That Pain Even After Subsequent Complete Cervical Spinal Cord Injury: Suggestions From a Prospective Case-Controlled Study.Archives of rehabilitation research and clinical translation · 2024Article
- A distributed brain response predicting the facial expression of acute nociceptive pain.bioRxiv : the preprint server for biology · 2024Article
- Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits.BMC medicine · 2023Article
- Preterm-birth alters the development of nodal clustering and neural connection pattern in brain structural network at term-equivalent age.Human brain mapping · 2023Article
- Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation.medRxiv : the preprint server for health sciences · 2023Article
- A study based on functional near-infrared spectroscopy: Cortical responses to music interventions in patients with myofascial pain syndrome.Frontiers in human neuroscience · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Recent studies indicate that a significant reorganization of cerebral networks may occur in patients with chronic pain, but how immediate pain experience influences the organization of large-scale functional networks is not yet well characterized. To investigate this question, we used functional magnetic resonance imaging in 106 participants experiencing both noxious and innocuous heat. Painful stimulation caused network-level reorganization of cerebral connectivity that differed substantially from organization during innocuous stimulation and standard resting-state networks. Noxious stimuli increased somatosensory network connectivity with (a) frontoparietal networks involved in context representation, (b) "ventral attention network" regions involved in motivated action selection, and (c) basal ganglia and brainstem regions. This resulted in reduced "small-worldness," modularity (fewer networks), and global network efficiency and in the emergence of an integrated "pain supersystem" (PS) whose activity predicted individual differences in pain sensitivity across 5 participant cohorts. Network hubs were reorganized ("hub disruption") so that more hubs were localized in PS, and there was a shift from "connector" hubs linking disparate networks to "provincial" hubs connecting regions within PS. Our findings suggest that pain reorganizes the network structure of large-scale brain systems. These changes may prioritize responses to painful events and provide nociceptive systems privileged access to central control of cognition and action during pain.
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Registered trials
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