ArticleStem cell reports2019
Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.
Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- 'Nomadic' Hematopoietic Stem Cells Navigate the Embryonic Landscape.Stem cell reviews and reports · 2025Review
- Sox17 and Other SoxF-Family Proteins Play Key Roles in the Hematopoiesis of Mouse Embryos.Cells · 2024Review
- Review
- A newly identified gene Ahed plays essential roles in murine haematopoiesis.Nature communications · 2024Article
- Article
- Murine models of clonal haematopoiesis to assess mechanisms of cardiovascular disease.Cardiovascular research · 2022Review
- Characterisation of canine CD34+/CD45 diminished cells by colony-forming unit assay and transcriptome analysis.Frontiers in veterinary science · 2022Article
- The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies.Stem cell reviews and reports · 2021Review
- mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate.Stem cell reviews and reports · 2021Review
- WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis.Stem cell research & therapy · 2021Article
- Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.Stem cells (Dayton, Ohio) · 2021Article
- The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells.International journal of molecular sciences · 2021Article
- Fetal liver hematopoiesis: from development to delivery.Stem cell research & therapy · 2021Review
- Negative Regulation of the Differentiation of Flk2International journal of molecular sciences · 2020Article
- RNA-seq reveals tight junction-relevant erythropoietic fate induced by OCT4 in human hair follicle mesenchymal stem cells.Stem cell research & therapy · 2020Article
- Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice.Stem cells international · 2020Review
- Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin.Frontiers in physiology · 2020Review
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial cell-selective adhesion molecule (ESAM) is a lifelong marker of hematopoietic stem cells (HSCs). Although we previously elucidated the functional importance of ESAM in HSCs in stress-induced hematopoiesis in adults, it is unclear how ESAM affects hematopoietic development during fetal life. To address this issue, we analyzed fetuses from conventional or conditional ESAM-knockout mice. Approximately half of ESAM-null fetuses died after mid-gestation due to anemia. RNA sequencing analyses revealed downregulation of adult-type globins and Alas2, a heme biosynthesis enzyme, in ESAM-null fetal livers. These abnormalities were attributed to malfunction of ESAM-null HSCs, which was demonstrated in culture and transplantation experiments. Although crosslinking ESAM directly influenced gene transcription in HSCs, observations in conditional ESAM-knockout fetuses revealed the critical involvement of ESAM expressed in endothelial cells in fetal lethality. Thus, we showed that ESAM had important roles in developing definitive hematopoiesis. Furthermore, we unveiled the importance of endothelial ESAM in this process.
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