ArticleNeuron2020
A Basal Forebrain-Cingulate Circuit in Macaques Decides It Is Time to Act.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Brain activity, disruption and connectivity comparisons identify origins of human metacognition in other primates.Nature human behaviour · 2026Article
- Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.Nature neuroscience · 2026Article
- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- Transcranial ultrasound stimulation selectively enhances fronto-temporal context-guided memory.bioRxiv : the preprint server for biology · 2025Article
- Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity.Nature communications · 2025Article
- Fundamental features of social environments determine rate of social affiliation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-invasive Ultrasonic Neuromodulation of the Human Nucleus Accumbens Impacts Reward Sensitivity.bioRxiv : the preprint server for biology · 2025Article
- Dorsal raphe nucleus controls motivation-state transitions in monkeys.Science advances · 2025Article
- The future of transcranial ultrasound as a precision brain interface.PLoS biology · 2024Article
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- Article
- General mechanisms of task engagement in the primate frontal cortex.Nature communications · 2024Article
- Neural activity ramps in frontal cortex signal extended motivation during learning.bioRxiv : the preprint server for biology · 2024Article
- Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans.IEEE transactions on bio-medical engineering · 2024Article
- Keeping time and rhythm by internal simulation of sensory stimuli and behavioral actions.Science advances · 2024Article
- A frontopolar-temporal circuit determines the impact of social information in macaque decision making.Neuron · 2024Article
- Controlled ultrasonic interventions through the human skull.Frontiers in human neuroscience · 2024Article
- Dynamic off-resonance correction improves functional image analysis in fMRI of awake behaving non-human primates.Frontiers in neuroimaging · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The medial frontal cortex has been linked to voluntary action, but an explanation of why decisions to act emerge at particular points in time has been lacking. We show that, in macaques, decisions about whether and when to act are predicted by a set of features defining the animal's current and past context; for example, respectively, cues indicating the current average rate of reward and recent previous voluntary action decisions. We show that activity in two brain areas-the anterior cingulate cortex and basal forebrain-tracks these contextual factors and mediates their effects on behavior in distinct ways. We use focused transcranial ultrasound to selectively and effectively stimulate deep in the brain, even as deep as the basal forebrain, and demonstrate that alteration of activity in the two areas changes decisions about when to act.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.