Cannibalism in Breast Cancer: The Dangers of Overeating.

Sue Haupt, Simon P Keam, Ygal Haupt

Abstract readComment

In one paragraph

Article in Trends in cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Fate of Entosis: From the Beginning to the End in Untreated Advanced Breast Cancer.International journal of molecular sciences · 2023
Article
Cellular Senescence: Mechanisms and Therapeutic Potential.Biomedicines · 2021
Review
Therapy-Induced Senescence: An "Old" Friend Becomes the Enemy.Cancers · 2020
Review
A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer Based upon Its Hydrogen Ion Dynamics.International journal of molecular sciences · 2020
Review

4 · The record

Corrections and comments

Comment on
Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival.2019

5 · Who and what money

Authors and funding

3 authors.

Sue HauptTumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

Simon P KeamTumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Cancer Immunology Research, Peter MacCallum Cancer Centre, Melbourne, Australia.

Ygal HauptTumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia. Electronic address: ygal.haupt@petermac.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells devouring their neighbours to survive drug treatment is an abhorrent concept. Yet it holds hope for exploring new anticancer treatments. Tonnessen-Murray et al. adopted elegant cell-labelling methods using real-time microscopy to observe 'cellular gorging' by drug-treated cells. They discovered that in response to drug treatment, cells that became 'cannibals' were able to outlive their unindulged neighbours.

Indexed as

Antineoplastic AgentsBreast NeoplasmsCannibalismHumansHyperphagiaAntineoplastic Agents

Identifiers

PMID31813452

DOI10.1016/j.trecan.2019.10.008

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.