Evidence map›Paper›PMID 31813381›Full record

ArticleBMC medicine2019

Differential impact of malaria control interventions on P. falciparum and P. vivax infections in young Papua New Guinean children.

Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  5. Molecular Screening ofAnimals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 6 countries.

Maria Ome-KaiusPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Johanna Helena KattenbergPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Sophie ZaloumisDepartment of Medical Biology, University of Melbourne, Melbourne, Australia.
Matthew SibaPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Benson KiniboroPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Shadrach JallyPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Zahra RazookWalter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Daisy MantilaPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Desmond SuiPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Jason GinnyPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Anna Rosanas-UrgellInstitute of Tropical Medicine, Antwerp, Belgium.
Stephan KarlPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Thomas ObadiaInstitut Pasteur, Paris, France.
Alyssa BarryWalter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Stephen J RogersonDepartment of Medical Biology, University of Melbourne, Melbourne, Australia.
Moses LamanPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Daniel TischCase Western Reserve University, Cleveland, USA.
Ingrid FelgerSwiss Tropical and Public Health Institute, Basel, Switzerland.
James W KazuraCase Western Reserve University, Cleveland, USA.
Ivo MuellerWalter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Leanne J RobinsonPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea. leanne.robinson@burnet.edu.au.ORCID 0000-0001-9903-1023
Papua New Guinea Institute of Medical Research · PGWalter and Eliza Hall Institute of Medical Research · AUThe University of Melbourne · AUCase Western Reserve University · USInstitut Pasteur · FRBurnet Institute · AUInstituut voor Tropische Geneeskunde · BESwiss Tropical and Public Health Institute · CH

Funding

TransmissionU19AI089686 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 2010 to 2016
$9.9M
Understanding, tracking and eliminating malaria transmission in the Asia - Pacific RegionU19AI129392 · NIAID · WALTER AND ELIZA HALL INST MEDICAL RES · PI Ivo J Mueller, Leanne Robinson · 2017 to 2026
$7.1M
The effect of mixed Plasmodium infections on morbidityR03AI063135 · NIAID · PAPUA NEW GUINEA INST/ MEDICAL RESEARCH · PI MUELLER, IVO · 2005 to 2006
$103k
NIAID NIH HHS R03 AI063135NIAID NIH HHS U19 AI089686NIAID NIH HHS U19 AI129392
6 · The paper itself

Abstract

introductionAs malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falciparum relative to Plasmodium vivax and identifying key drivers of ongoing transmission is essential to guide future interventions.

methodsThree longitudinal child cohorts were conducted in Papua New Guinea before (2006/2007), during (2008) and after scale-up of control interventions (2013). In each cohort, children aged 1-5 years were actively monitored for infection and illness. Incidence of malaria episodes, molecular force of blood-stage infections (

resultsBetween 2006 and 2008, P. falciparum infection prevalence,

conclusionIntensified vector control and routine case management had a differential impact on rates of P. falciparum and P. vivax infections but not clinical malaria episodes in young children. This suggests comparable reductions in new mosquito-derived infections but a delayed impact on P. vivax relapsing infections due to a previously acquired reservoir of hypnozoites. This demonstrates the need to strengthen implementation of P. vivax radical cure to maximise impact of control in co-endemic areas. The high heterogeneity of malaria in 2013 highlights the importance of surveillance and targeted interventions to accelerate towards elimination.

Indexed as

AnimalsChild, PreschoolFemaleHumansIncidenceInfantLongitudinal StudiesMalaria, FalciparumMalaria, VivaxMalePapua New GuineaPlasmodium falciparumPlasmodium vivaxPrevalenceRisk FactorsEpidemiologyIncidenceMalaria controlPapua New GuineaP. falciparumPrevalenceP. vivax

Identifiers

PMID31813381
PMCPMC6900859
OpenAlexW2994894146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.