Evidence map›Paper›PMID 31813252›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Effect of sex differences in treatment response to angioplasty in a murine arteriovenous fistula model.

Chuanqi Cai, Chenglei Zhao, Sreenivasulu Kilari, Amit Sharma, Avishek K Singh, Michael L Simeon, Avanish Misra, Yiqing Li, Sanjay Misra

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  5. The rodent models of arteriovenous fistula.Frontiers in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Chuanqi CaiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chenglei ZhaoVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Sreenivasulu KilariVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Amit SharmaVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Avishek K SinghVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Michael L SimeonVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Avanish MisraVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Yiqing LiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sanjay MisraVascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic in Arizona · USHuazhong University of Science and Technology · CNMayo Clinic · USSecond Xiangya Hospital of Central South University · CN

Funding

The Role of Hypoxia In Venous Neointimal Hyperplasia In Hemodialysis GraftsR01HL098967 · NHLBI · MAYO CLINIC ROCHESTER · PI Sanjay Misra · 2010 to 2026
$10.4M
Regulatory gene-chemokine networks in the formation of hemodialysis AVF stenosisR01DK107870 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV, MISRA, SANJAY · 2017 to 2019
$716k
Regulatory gene-chemokine networks in the formation of hemodialysis AVF stenosisR56DK107870 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV, MISRA, SANJAY · 2020 to 2020
$103k
NHLBI NIH HHS R01 HL098967NIDDK NIH HHS R01 DK107870NIDDK NIH HHS R56 DK107870
6 · The paper itself

Abstract

Failure to mature and venous neointimal hyperplasia formation are the two major causes of hemodialysis arteriovenous fistula (AVF) vascular access failure. Percutaneous transluminal angioplasty (PTA) is the firstline treatment for both of these conditions, but, clinically, women have decreased patency rates compared with men. The hypothesis to be tested in the present study was that female mice after PTA of venous areas of higher intimal thickening have increased gene expression of transforming growth factor-β1 (TGF-β1) and TGF-β receptor 1 (TGFβ-R1) accompanied with histological changes of fibrosis compared with male mice. Seventeen male and eighteen female C57BL/6J mice were used in this study. Chronic kidney disease was induced by partial nephrectomy, and, 28 days later, an AVF was created to connect the left carotid artery to the right jugular vein. Two weeks later, the higher intimal thickening area was treated with PTA, and mice were euthanized 3 days later for gene expression analysis or 14 days later for histopathological analysis. Doppler ultrasound was performed weekly after AVF creation. At

Indexed as

AngioplastyActinsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticArginaseArteriovenous FistulaCD68 MoleculeFemaleGene Expression RegulationMaleMice, Inbred C57BLMyosin Heavy ChainsPlatelet Endothelial Cell Adhesion Molecule-1Receptor, Transforming Growth Factor-beta Type IS100 Calcium-Binding Protein A4Actinsalpha-smooth muscle actin, mouseAntigens, CDAntigens, Differentiation, MyelomonocyticArg1 protein, mouseArginaseCD68 MoleculeCD68 protein, mousemyosin 11, mouseMyosin Heavy ChainsPlatelet Endothelial Cell Adhesion Molecule-1Receptor, Transforming Growth Factor-beta Type IS100a4 protein, mouseS100 Calcium-Binding Protein A4Transforming Growth Factor beta1angioplastyarteriovenous fistulamurine modelrestenosissexual disparity

Identifiers

PMID31813252
PMCPMC7099504
OpenAlexW2996581119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.