ArticleCerebral cortex (New York, N.Y. : 1991)2020
Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Overexpression of Synaptopodin increases the number of spine apparatuses and active synapses of dentate granule cells.Scientific reports · 2026Article
- Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices.Hippocampus · 2025Article
- Ectopic reconstitution of a spine-apparatus-like structure provides insight into mechanisms underlying its formation.Current biology : CB · 2025Article
- Retinoic acid modulation of granule cell activity and spatial discrimination in the adult hippocampus.Frontiers in cellular neuroscience · 2024Article
- All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells.eLife · 2021Article
- Location, location, location: the organization and roles of potassium channels in mammalian motoneurons.The Journal of physiology · 2021Article
- High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus.Scientific reports · 2021Article
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5 authors.
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Abstract
The plasticity-related protein Synaptopodin (SP) has been implicated in neuronal plasticity. SP is targeted to dendritic spines and the axon initial segment, where it organizes the endoplasmic reticulum (ER) into the spine apparatus and the cisternal organelle, respectively. Here, we report an inducible third localization of SP in the somata of activated granule cell ensembles in mouse dentate gyrus. Using immunofluorescence and fluorescence in situ hybridization, we observed a subpopulation of mature granule cells (~1-2%) exhibiting perinuclear SP protein and a strong somatic SP mRNA signal. Double immunofluorescence labeling for Arc demonstrated that ~ 75% of these somatic SP-positive cells are also Arc-positive. Placement of mice into a novel environment caused a rapid (~2-4 h) induction of Arc, SP mRNA, and SP protein in exploration-induced granule cell ensembles. Lesion experiments showed that this induction requires input from the entorhinal cortex. Somatic SP colocalized with α-Actinin2, a known binding partner of SP. Finally, ultrastructural analysis revealed SP immunoprecipitate on dense plates linking cytoplasmic and perinuclear ER cisterns; these structures were absent in granule cells of SP-deficient mice. Our data implicate SP in the formation of contextual representations in the dentate gyrus and the behaviorally induced reorganization of cytoplasmic and perinuclear ER.
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