ArticleJournal of the neurological sciences2020
Ingested ACTH blocks Th17 production by inhibiting GALT IL-6.
Article in Journal of the neurological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- The Therapeutic Effects of Purified Cortrophin Gel on Experimental Autoimmune Uveitis.Ocular immunology and inflammation · 2025Article
- Understanding the Immune System's Intricate Balance: Activation, Tolerance, and Self-Protection.International journal of molecular sciences · 2025Review
- Effects of Psychological Stress on Multiple SclerosisCNS & neurological disorders drug targets · 2024Review
- A Perspective on Oral Immunotherapeutic Tools and Strategies for Autoimmune Disorders.Vaccines · 2023Review
- Article
- Ingested (Oral) Adrenocorticotropic Hormone Inhibits IL-17 in the Central Nervous System in the Mouse Model of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.ImmunoHorizons · 2022Article
- Microbial and metabolic characterization of organic artisanal sauerkraut fermentation and study of gut health-promoting properties of sauerkraut brine.Frontiers in microbiology · 2022Article
- Serum IL-6 as a marker of disease progression in interstitial nephritis.American journal of translational research · 2022Article
- ACTH treatment promotes murine cardiac allograft acceptance.JCI insight · 2021Article
- Multifactorial expression of IL-6 with update on COVID-19 and the therapeutic strategies of its blockade (Review).Experimental and therapeutic medicine · 2021Review
- Hormones in experimental autoimmune encephalomyelitis (EAE) animal models.Translational neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEAE is an inflammatory autoimmune process of the CNS that resembles multiple sclerosis (MS) and provides a useful animal model for the evaluation of mechanisms of action for potential immunomodulatory therapies. Oral ACTH (adrenocorticotropic hormone) can decrease clinical disease, IL-17 and Th1-like encephalitogenic IFN-γ secretion and increase T
objectiveIL-6 is a pivotal cytokine in the gut that determines the relative frequencies of Th17 vs T DESIGN/
methodsB6 mice were immunized with MOG peptide 35-55 and gavaged with scrambled ACTH (scrambled melanocyte stimulating hormone [scrambled α-MSH]) or ACTH 1-39 during ongoing disease.
resultsIngested (oral) ACTH inhibited ongoing clinical disease. In the lamina propria (LP) immune compartment, there were significantly less CD11b + IL-6 and IL-17 producing lymphocytes from ACTH fed mice compared to s-MSH fed mice. There was also a decrease in the frequency of IL-17 and IFN-γ producing spleen cells and an increase in CD4 + FoxP3+ T
conclusionsIngested ACTH inhibits EAE clinical disease by inhibiting IL-6 in the GALT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.