ArticleiScience2019
Co-existence of Network Architectures Supporting the Human Gut Microbiome.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
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- Starvation Influences the Microbiota in the Stomach of the Corallivorous Crown-of-Thorns Starfish.Biology · 2025Article
- Gut microbiota maturation and early behavioral and cognitive development.Scientific reports · 2025Article
- MiCoDe: a web tool for performing microbiome community detection using a Bayesian weighted stochastic block model.Bioinformatics (Oxford, England) · 2025Article
- A Generalized Bayesian Stochastic Block Model for Microbiome Community Detection.Statistics in medicine · 2025Article
- Topology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults.Phenomics (Cham, Switzerland) · 2025Article
- Networking the desert plant microbiome, bacterial and fungal symbionts structure and assortativity in co-occurrence networks.Environmental microbiome · 2024Article
- Integration of metataxonomic data sets into microbial association networks highlights shared bacterial community dynamics in fermented vegetables.Microbiology spectrum · 2024Article
- Article
- Site-Specific Gut Microbial Signatures in Non-Celiac Gluten Sensitivity.Gut microbes reports · 2024Article
- Inflammatory bowel disease biomarkers revealed by the human gut microbiome network.Scientific reports · 2023Article
- Selective enrichment of founding reproductive microbiomes allows extensive vertical transmission in a fungus-farming termite.Proceedings. Biological sciences · 2023Article
- Vitamin BMicrobiome · 2023Article
- The Alteration of Akkermansiaceae/Lachnospiraceae Ratio Is a Microbial Feature of Antibiotic-Induced Microbiota Remodeling.Bioinformatics and biology insights · 2023Article
- Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection.Frontiers in microbiology · 2022Article
- Microbial community networks across body sites are associated with susceptibility to respiratory infections in infants.Communications biology · 2021Article
- Disinfection of Maternal Environments Is Associated with Piglet Microbiome Composition from Birth to Weaning.mSphere · 2021Article
- A zero inflated log-normal model for inference of sparse microbial association networks.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial organisms of the human gut microbiome do not exist in isolation but form complex and diverse interactions to maintain health and reduce risk of disease development. The organization of the gut microbiome is assumed to be a singular assortative network, where interactions between operational taxonomic units (OTUs) can readily be clustered into segregated and distinct communities. Here, we leverage recent methodological advances in network modeling to assess whether communities in the human microbiome exhibit a single network structure or whether co-existing mesoscale network architectures are present. We found evidence for core-periphery structures in the microbiome, supported by strong, assortative community interactions. This complex architecture, coupled with previously reported functional roles of OTUs, provides a nuanced understanding of how the microbiome simultaneously promotes high microbial diversity and maintains functional redundancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.