ArticleiScience2019
Nickel/Brønsted Acid-Catalyzed Chemo- and Enantioselective Intermolecular Hydroamination of Conjugated Dienes.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Nickel-catalyzed divergent sulfonations of propargylic carbonate.Nature communications · 2026Article
- Theoretical study of Ni(0)-catalyzed intermolecular hydroamination of branched 1,3-dienes: reaction mechanism, regioselectivity, enantioselectivity, and prediction of the ligand.Journal of molecular modeling · 2024Article
- CoH-catalyzed asymmetric remote hydroalkylation of heterocyclic alkenes: a rapid approach to chiral five-membered S- and O-heterocycles.Chemical science · 2024Article
- NiH-catalyzed C-N bond formation: insights and advancements in hydroamination of unsaturated hydrocarbons.Chemical science · 2024Review
- Palladium-Catalyzed Regiodivergent Three-Component Alkenylamination of 1,3-Dienes with Alkyl and Aryl Amines.Journal of the American Chemical Society · 2023Article
- Scope and Mechanistic Probe into Asymmetric Synthesis of α-Trisubstituted-α-Tertiary Amines by Rhodium Catalysis.Journal of the American Chemical Society · 2023Article
- Practical synthesis of allylic aminesChemical science · 2023Article
- Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis.Journal of the American Chemical Society · 2023Article
- Ni-Catalyzed Enantioselective Hydrofunctionalizations of 1,3-Dienes.ACS catalysis · 2022Review
- Nickel/Brønsted acid dual-catalyzed regio- and enantioselective hydrophosphinylation of 1,3-dienes: access to chiral allylic phosphine oxides.Chemical science · 2022Article
- Article
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Authors and funding
5 authors.
Funding
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Abstract
A novel nickel/Brønsted acid-catalyzed asymmetric hydroamination of acyclic 1,3-dienes has been established. A wide array of primary and secondary amines can be transformed into allylic amines with high yields and high enantioselectivities under very mild conditions. Moreover, our method is compatible with various functional groups and heterocycles, allowing for late-stage functionalization of biologically active complex molecules. Remarkably, this protocol exhibits good chemoselectivity with respect to amines bearing two different nucleophilic sites. Mechanistic studies reveal that the enantioselective carbon-nitrogen bond-forming step is reversible.
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