Evidence map›Paper›PMID 31812759›Full record

ArticlePharmacology, biochemistry, and behavior2020

The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine.

Natalie Nardone, Marian Shahid, Andrew A Strasser, Delia A Dempsey, Neal L Benowitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Natalie NardoneClinical Pharmacology Research Program, Division of Cardiology, Department of Medicine, University of California, San Francisco, 3130 20(th) Street Suite 308, San Francisco, CA 94110, USA. Electronic address: natalie.nardone@ucsf.edu.
Marian ShahidDepartment of Neurology, Stanford University, 300 Pasteur Dr. Room H3144, MC 5235, Stanford, CA 94305, USA. Electronic address: mshahid@stanford.edu.
Andrew A StrasserDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street Suite 4100, Philadelphia, PA 19104, USA. Electronic address: strasse3@mail.med.upenn.edu.
Delia A DempseyClinical Pharmacology Research Program, Division of Cardiology, Department of Medicine, University of California, San Francisco, 3130 20(th) Street Suite 308, San Francisco, CA 94110, USA; Department of Pediatrics, University of California, San Francisco, 550 16(th) Street, Box 0110, San Francisco, CA 94143, USA. Electronic address: delia.dempsey@ucsf.edu.
Neal L BenowitzCenter for Tobacco Control Research and Education, University of California, San Francisco, 530 Parnassus Avenue, San Francisco, CA 94143, USA; Division of Clinical Pharmacology and Experiment Therapeutics, Departments of Medicine and Biopharmaceutical Sciences, University of California, San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA. Electronic address: neal.benowitz@ucsf.edu.
University of California, San Francisco · USStanford University · USUniversity of Pennsylvania · US

Funding

Mechanisms of the Nicotine Metabolism Effect on Tobacco DependenceR01DA031193 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENOWITZ, NEAL L · 2012 to 2014
$1.2M
NIDA NIH HHS R01 DA031193
6 · The paper itself

Abstract

backgroundA faster rate of nicotine metabolism has been associated with smoking more cigarettes, greater nicotine withdrawal symptoms, and lower smoking quit rates. However, the association between nicotine metabolic rate (NMR) and cognitive functioning during withdrawal has not been determined.

methodsWe compared cognitive function in 121 fast or slow nicotine metabolizers after smoking, and at 3 and 6 h of nicotine abstinence. Cognitive functioning was assessed using N-back working memory tests with outcomes of accuracy and processing speed. Participants smoked two cigarettes and then abstained from smoking for 6 h. N-back tests were administered after smoking (0 h) and at 3 and 6 h of nicotine abstinence.

resultsAn effect of processing speed was found over time on the 2-back, in that participants had significantly longer average reaction times when the stimuli presented did not match the target letter. NMR was not significantly associated with the processing speed change over time. Within-race differences in working memory were evident in that Caucasian fast metabolizers had significantly poorer accuracy and processing speed.

conclusionsMinimal change in working memory over 6 h of nicotine abstinence was observed. Overall, NMR was not significantly associated with the change in processing speed, however Caucasian fast metabolizers displayed poorer accuracy and processing speed at discrete time points.

Indexed as

AdultCigarette SmokingCognitionFemaleHumansMagnetic Resonance SpectroscopyMaleMemory, Short-TermMiddle AgedNicotineProspective StudiesReaction TimeSmoking CessationTime FactorsYoung AdultNicotineCognitionNicotineNicotine metabolite ratioNMRSmokingWorking memory

Identifiers

PMID31812759
PMCPMC7009742
OpenAlexW2992881199

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.