ArticleJournal of the American Academy of Dermatology2023
Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study.
Article in Journal of the American Academy of Dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review.Journal of the American Academy of Dermatology · 2021Pooled it
- International Dermoscopy Society consensus recommendations for the management of lentigo maligna.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- Reflectance confocal microscopy in the management of lentigo maligna and lentigo maligna melanoma: a systematic review.JPRAS open · 2026Review
- Mohs Micrographic Surgery: A Narrative Review of Current Practices, Emerging Trends, and Case-Based Insights.Advances in therapy · 2025Review
- Lentigo Maligna Treatment-An Update.Journal of clinical medicine · 2024Review
- Perifollicular linear projections: A dermatoscopic criterion for the diagnosis of lentigo maligna on the face.Journal of the American Academy of Dermatology · 2024Article
- Delphi Consensus Among International Experts on the Diagnosis, Management, and Surveillance for Lentigo Maligna.Dermatology practical & conceptual · 2023Article
- Water-based acrylic marker for reflectance confocal microscopy lesion delineation.Lasers in surgery and medicine · 2022Article
- Patterns of the use of reflectance confocal microscopy at a tertiary referral dermatology clinic.Journal of the American Academy of Dermatology · 2022Article
- Optical imaging guided- 'precision' biopsy of skin tumors: a novel approach for targeted sampling and histopathologic correlation.Archives of dermatological research · 2021Observational
- Correlation between Autofluorescence Intensity and Histopathological Features in Non-Melanoma Skin Cancer: An Ex Vivo Study.Cancers · 2021Article
- Clinical size is a poor predictor of invasion in melanoma of the lentigo maligna type.Journal of the American Academy of Dermatology · 2021Article
- Management of complex head-and-neck basal cell carcinomas using a combined reflectance confocal microscopy/optical coherence tomography: a descriptive study.Archives of dermatological research · 2021Observational
- Treatment of Extramammary Paget Disease and the Role of Reflectance Confocal Microscopy: A Prospective Study.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2021Article
- Incompletely excised lentigo maligna melanoma is associated with unpredictable residual disease: clinical features and the emerging role of reflectance confocal microscopy.Journal of the European Academy of Dermatology and Venereology : JEADV · 2020Article
- A case of recurrent lentigo maligna diagnosed with precise reflectance confocal microscopy-guided biopsy technique.JAAD case reports · 2020Article
- Lentigo Maligna: Clinical Presentation and Appropriate Management.Clinical, cosmetic and investigational dermatology · 2020Review
- Management of periocular keratinocyte carcinomas with Mohs micrographic surgery and predictors of complex reconstruction: a retrospective study.Anais brasileiros de dermatologiaArticle
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Abstract
backgroundLentigo maligna/lentigo maligna melanoma (LM/LMM) can present with subclinical extension that may be difficult to define preoperatively and lead to incomplete excision and potential recurrence. Preliminarily studies have used reflectance confocal microscopy (RCM) to assess LM/LMM margins.
objectiveTo evaluate the correlation of LM/LMM subclinical extension defined by RCM compared with the gold standard histopathology.
methodsProspective study of LM/LMM patients referred for dermatologic surgery. RCM was performed at the clinically defined initial surgical margin followed by margin-controlled staged excision with paraffin-embedded tissue, and histopathology was correlated with RCM results.
resultsSeventy-two patients were included. Mean age was 66.8 years (standard deviation, 11.1; range, 38-89); 69.4% were men. Seventy of 72 lesions (97.2%) were located on the head and neck with mean largest clinical diameter of 1.3 cm (range, 0.3-5). Diagnostic accuracy for detection of residual melanoma in the tumor debulk (after biopsy) had a sensitivity of 96.7% and a specificity of 66.7% when compared with histopathology. RCM margin assessment revealed an overall agreement with final histopathology of 85.9% (κ = 0.71; P < .001). LIMITATIONS: No RCM imaging beyond initial planned margins was performed.
conclusionRCM showed moderate to excellent overall agreement between RCM imaging of LM/LMM and histopathology of staged excision margins.
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