Evidence map›Paper›PMID 31812324›Full record

ArticleBioorganic & medicinal chemistry2020

Lipidated α/Sulfono-α-AA heterogeneous peptides as antimicrobial agents for MRSA.

Sylvia Singh, Minghui Wang, Ruixuan Gao, Peng Teng, Timothy Odom, En Zhang, Hai Xu, Jianfeng Cai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sylvia SinghDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States.
Minghui WangDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States.
Ruixuan GaoDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States.
Peng TengDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States.
Timothy OdomDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States.
En ZhangDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China.
Hai XuCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
Jianfeng CaiDepartment of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, United States. Electronic address: hshim@emory.edu.
University of South Florida · USCentral South University · CN

Funding

Requesting HPLC for the project of "Alpha-AApeptides as a Novel Class of Antimicrobial Biomaterials"R01GM112652 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM112652
6 · The paper itself

Abstract

Though antibiotics have been used for decades to treat bacterial infections, there is a great need for new treatment methods. Bacteria are becoming resistant to conventional antibiotics, as is the case with Methicillin resistant Staphylococcus aureus (MRSA). Herein we report the design of a series of lipidated α/Sulfono-α-AA heterogeneous peptides as mimics for Host Defense Peptides (HDPs). Utilizing fluorescence microscopy and depolarization techniques, our compounds demonstrate the ability to kill Gram-positive bacteria through cell membrane disruption. This mechanism of action makes it difficult for bacteria to develop resistance. Further time kill studies and hemolytic assays have also proven these compounds to be efficient in their ability to eradicate bacteria cells while remaining non-toxic to human red blood cells. This new class of peptidomimetics shows promise for the future antibiotic treatment of MRSA.

Indexed as

Anti-Bacterial AgentsDose-Response Relationship, DrugHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicroscopy, FluorescenceMolecular StructurePeptidesStructure-Activity RelationshipAnti-Bacterial AgentsPeptidesAntimicrobialBacterial resistanceHost Defense PeptidesLipidationPeptidomimetics

Identifiers

PMID31812324
PMCPMC10523340
OpenAlexW2990159184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.