ArticlePediatric research2020
Long-term neurological effects of neonatal caffeine treatment in a rabbit model of preterm birth.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Protective Effects of Early Neonatal Methylxanthine Treatment on Cognitive and Language Outcomes in Premature Infants with and without High-Risk Perinatal Factors.Developmental neuroscience · 2025Article
- How to translate neurocognitive and behavioural outcome data in animals exposed to paracetamol to the human perinatal setting?Archives of medical science : AMS · 2024Article
- Cardiorespiratory and Neuroprotective Effects of Caffeine in Neonate Animal Models.Animals : an open access journal from MDPI · 2023Review
- Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model.Pediatric research · 2022Article
- Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.CNS neuroscience & therapeutics · 2022Article
- Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit ModelsFrontiers in toxicology · 2022Article
- Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model.Fetal diagnosis and therapy · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal caffeine treatment might affect brain development. Long-term studies show conflicting results on brain-related outcomes. Herein we aimed to investigate the long-term effects of neonatal caffeine administration in a rabbit model of preterm birth.
methodsPreterm (born day 29) and term (day 32) pups were raised by wet nurses and allocated to treatment with saline or caffeine for 7 or 17 days. At pre-puberty, neurobehavioral tests were performed and brains were harvested for immunostaining of neurons, synapses, myelin, and astrocytes.
resultsSurvival was lower in preterm saline pups than in controls, whereas caffeine-treated preterm pups did not differ from term control pups. Preterm saline pups covered less distance compared to controls and were more likely to stay in the peripheral zone of the open field. Corresponding differences were not seen in preterm caffeine pups. Preterm animals had lower neuron density compared to controls, which was not influenced by caffeine treatment. Synaptic density, astrocytes, and myelin were not different between groups.
conclusionCaffeine appeared to be safe. All preterm rabbits had lower neuron density but anxious behavior seen in preterm saline rabbits was not seen in caffeine-treated preterm pups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.