Evidence map›Paper›PMID 31812152›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain.

Antony D Abraham, Edward J Y Leung, Brenden A Wong, Zeena M G Rivera, Lauren C Kruse, Jeremy J Clark, Benjamin B Land

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Article
  3. The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Chewable Tablets for Precise Unit Dosing of Animals.Journal of pharmaceutical innovation · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Unveiling the link between chronic pain and misuse of opioids and cannabis.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Antony D Abraham *Department of Pharmacology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Edward J Y Leung *Department of Pharmacology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Brenden A WongDepartment of Pharmacology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Zeena M G RiveraDepartment of Pharmacology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0001-8506-5097
Lauren C KruseDepartment of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Jeremy J ClarkDepartment of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA.
Benjamin B LandDepartment of Pharmacology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA. BBL2@uw.edu.
Seattle Pacific University · USUniversity of Washington · US

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
p38 MAPK Mechanisms of Kappa Opioid-Induced BehaviorsR01DA030074 · NIDA · UNIVERSITY OF WASHINGTON · PI CHAVKIN, CHARLES · 2011 to 2020
$3.2M
NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA030074
6 · The paper itself

Abstract

Chronic pain affects a significant percentage of the United States population, and available pain medications like opioids have drawbacks that make long-term use untenable. Cannabinoids show promise in the management of pain, but long-term treatment of pain with cannabinoids has been challenging to implement in preclinical models. We developed a voluntary, gelatin oral self-administration paradigm that allowed male and female mice to consume ∆

Indexed as

CannabinoidsChronic PainHyperalgesiaNeuralgiaAdministration, OralAnimalsCannabidiolDisease Models, AnimalDronabinolDrug ToleranceFemaleMaleMiceMorphineSciatic NerveSelf AdministrationCannabidiolCannabinoidsDronabinolMorphine

Identifiers

PMID31812152
PMCPMC7235274
OpenAlexW2993202212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.