Evidence map›Paper›PMID 31811900›Full record

ArticleNeuroImage2020

Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging.

Caroline Guglielmetti, Tanguy Boucneau, Peng Cao, Annemie Van der Linden, Peder E Z Larson, Myriam M Chaumeil

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Quantification of the in vivo brain ultrashort-TMagnetic resonance in medicine · 2024
    Article
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  7. Review
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  9. Review
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  12. Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Caroline GuglielmettiDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; Bio-Imaging Laboratory, Department of Biomedical Sciences, University of Antwerp, 2000, Antwerp, Belgium.
Tanguy BoucneauDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Peng CaoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Annemie Van der LindenBio-Imaging Laboratory, Department of Biomedical Sciences, University of Antwerp, 2000, Antwerp, Belgium.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, Berkeley and University of California, San Francisco, CA, USA.
Myriam M ChaumeilDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, Berkeley and University of California, San Francisco, CA, USA. Electronic address: myriam.chaumeil@ucsf.edu.
University of California, San Francisco · USAmerican Physical Therapy Association · USUniversity of Antwerp · BEUniversity of California, Berkeley · US

Funding

MR Metabolic Imaging of Multiple SclerosisR01NS102156 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy William Gordon, Ari J Green · 2017 to 2026
$3.4M
Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS LymphomaR01CA239462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, RUBENSTEIN, JAMES LOUIS · 2019 to 2023
$3.1M
Novel Ultrashort Echo Time Sequences for Brain MRIR21NS089004 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2016 to 2017
$436k
In vivo metabolic imaging of neuroinflammation after TBIR21NS096718 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, ROSI, SUSANNA · 2016 to 2017
$436k
NCI NIH HHS R01 CA239462NINDS NIH HHS R01 NS102156NINDS NIH HHS R21 NS089004NINDS NIH HHS R21 NS096718
6 · The paper itself

Abstract

Alterations in myelin integrity are involved in many neurological disorders and demyelinating diseases, such as multiple sclerosis (MS). Although magnetic resonance imaging (MRI) is the gold standard method to diagnose and monitor MS patients, clinically available MRI protocols show limited specificity for myelin detection, notably in cerebral grey matter areas. Ultrashort echo time (UTE) MRI has shown great promise for direct imaging of lipids and myelin sheaths, and thus holds potential to improve lesion detection. In this study, we used a sequence combining magnetization transfer (MT) with UTE ("UTE-MT", TE ​= ​76 ​μs) and with short TE ("STE-MT", TE ​= ​3000 ​μs) to evaluate spatial and temporal changes in brain myelin content in the cuprizone mouse model for MS on a clinical 7 ​T scanner. During demyelination, UTE-MT ratio (UTE-MTR) and STE-MT ratio (STE-MTR) values were significantly decreased in most white matter and grey matter regions. However, only UTE-MTR detected cortical changes. After remyelination in subcortical and cortical areas, UTE-MTR values remained lower than baseline values, indicating that UTE-MT, but not STE-MT, imaging detected long-lasting changes following a demyelinating event. Next, we evaluated the potential correlations between imaging values and underlying histopathological markers. The strongest correlation was observed between UTE-MTR and percent coverage of myelin basic protein (MBP) immunostaining (r

Indexed as

Myelin SheathRemyelinationAnimalsCerebral CortexCuprizoneDisease Models, AnimalFemaleGray MatterMagnetic Resonance ImagingMiceMonoamine Oxidase InhibitorsMultiple SclerosisNeuroimagingWhite MatterCuprizoneMonoamine Oxidase InhibitorsCuprizoneDemyelinationMagnetization transferMultiple sclerosisMyelinUltrashort echo time

Identifiers

PMID31811900
PMCPMC6953605
OpenAlexW2993825770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.