Evidence map›Paper›PMID 31811639›Full record

ArticleTranslational stroke research2020

Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke Model.

Samantha E Spellicy, Erin E Kaiser, Michael M Bowler, Brian J Jurgielewicz, Robin L Webb, Franklin D West, Steven L Stice

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  16. Frontiers in pharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha E SpellicyRegenerative Bioscience Center, University of Georgia, Athens, GA, 30602, USA.ORCID https://orcid.org/0000-0001-5648-8816
Erin E KaiserRegenerative Bioscience Center, University of Georgia, Athens, GA, 30602, USA.
Michael M BowlerRegenerative Bioscience Center, University of Georgia, Athens, GA, 30602, USA.
Brian J JurgielewiczRegenerative Bioscience Center, University of Georgia, Athens, GA, 30602, USA.ORCID https://orcid.org/0000-0001-9900-8077
Robin L WebbArunA Biomedical, Athens, GA, 30602, USA.
Franklin D WestRegenerative Bioscience Center, University of Georgia, Athens, GA, 30602, USA.ORCID https://orcid.org/0000-0002-0504-7997
Steven L SticeRegenerative Bioscience Center, University of Georgia, Athens, GA, 30602, USA. sstice@uga.edu.ORCID https://orcid.org/0000-0001-5710-5872

Funding

National Science Foundation CBET-0939511NIH HHS 1R43NS103596-01
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a stroke intervention is withheld or provided, in order to identify biomarkers for stroke functional outcome under these conditions. Fifteen MRI and ninety functional parameters were measured in a middle cerebral artery occlusion (MCAO) porcine ischemic stroke model. Multiparametric analysis of correlations between MRI measurements and functional outcome was conducted. Acute axial and coronal midline shift (MLS) at 24 h post-stroke were associated with decreased survival and recovery measured by modified Rankin scale (mRS) and were significantly correlated with 52 measured acute (day 1 post) and chronic (day 84 post) gait and behavior impairments in non-treated stroked animals. These results suggest that MLS may be an important non-invasive biomarker that can be used to predict patient outcomes and prognosis as well as guide therapeutic intervention and rehabilitation in non-treated animals and potentially human patients that do not receive interventional treatments. Neural stem cell-derived extracellular vesicle (NSC EV) was a disruptive therapy because NSC EV administration post-stroke disrupted MLS correlations observed in non-treated stroked animals. MLS was not associated with survival and functional outcomes in NSC EV-treated animals. In contrast to untreated animals, NSC EVs improved stroked animal outcomes regardless of MLS severity.

Indexed as

AnimalsBrainBrain IschemiaDisease Models, AnimalExtracellular VesiclesInfarction, Middle Cerebral ArteryIschemic StrokeMagnetic Resonance ImagingMaleNeural Stem CellsSwineExtracellular vesiclesMagnetic brain imagingNeural stem cellsNeuroimagingStrokeSwine

Identifiers

PMID31811639
PMCPMC7340639

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.