Evidence map›Paper›PMID 31811603›Full record

ReviewMycopathologia2019

Talaromycosis (Penicilliosis) Due to Talaromyces (Penicillium) marneffei: Insights into the Clinical Trends of a Major Fungal Disease 60 Years After the Discovery of the Pathogen.

Cunwei Cao, Liyan Xi, Vishnu Chaturvedi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mycopathologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 4 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 4 syntheses or guidelines pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Rapid diagnosis ofFrontiers in cellular and infection microbiology · 2022
    Pooled it
  4. GastrointestinalFrontiers in immunology · 2022
    Pooled it
  5. Article
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  9. Glutathione Peroxidase fromInternational journal of molecular sciences · 2026
    Article
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  12. Special pathogen infections presenting with neck mass as the initial manifestation.Frontiers in cellular and infection microbiology · 2026
    Article
  13. Clinical Features and Diagnostic Challenges ofInfection and drug resistance · 2026
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  17. Review
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Cunwei CaoThe Department of Dermatology and Venereology, The First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi, China. caocunwei@yeah.net.
Liyan XiDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Vishnu ChaturvediMycology Laboratory, Wadsworth Center New York State Department of Health, Albany, NY, USA.ORCID http://orcid.org/0000-0002-3922-9676
Guangxi University · CNNew York State Department of Health · USSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Talaromycosis (penicilliosis) is a major fungal disease endemic across a narrow band of tropical countries of South and Southeast Asia. The etiologic agent is a thermally dimorphic fungus Talaromyces (Penicillium) marneffei, which was first isolated from a bamboo rat in Vietnam in 1956, but no formal description was published. In 1959, Professor Gabriel Segretain formally described it as a novel species Talaromyces (Penicillium) marneffei, and the human pathogenic potential of the fungus in Mycopathologia. The first natural human case of talaromycosis (penicillosis) was reported in 1973 and involved an American minister with Hodgkin's disease who lived in Southeast Asia. Sixty years after the discovery of the pathogen, talaromycosis caused by T. marneffei is recognized as an important human disease with the potential to cause high mortality in the absence of proper diagnosis and prompt treatment. Talaromycosis remains a significant infectious complication in HIV/AIDS patients and in patients with other immune defects. The disease is being recognized with an increasing frequency well beyond the traditional endemic areas. The natural reservoirs of T. marneffei in wild rodents are well-defined, which links the ecology with the epidemiology of talaromycosis in endemic areas. There is an urgent unmet need for rapid and affordable point-of-care diagnostic tests. We also need more clinical studies to define the best therapeutic options for the management of talaromycosis patients.

Indexed as

MycosesTalaromycesAIDS-Related Opportunistic InfectionsAnimalsAntifungal AgentsDisease ReservoirsHumansMortalityPrevalenceRisk FactorsAntifungal AgentsAnniversaryClinical trendsSixty yearsTalaromyces marneffeiTalaromycosis

Identifiers

PMID31811603
OpenAlexW2992850859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.