Evidence map›Paper›PMID 31811565›Full record

ArticleMolecular neurobiology2020

Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis.

Abdel G Elkahloun, Juan M Saavedra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Neuropeptides and Their Roles in the Cerebellum.International journal of molecular sciences · 2024
    Review
  2. Review
  3. Candesartan could ameliorate the COVID-19 cytokine storm.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Abdel G ElkahlounComparative Genomics and Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-1749-740X
Juan M SaavedraDepartment of Pharmacology and Physiology, Georgetown University Medical Center, SE402 Med/Dent, 3900 Reservoir Road, Washington, DC, 20057, USA. juan.saavedra@georgetown.edu.ORCID http://orcid.org/0000-0002-7238-9647
Georgetown University · USNational Institutes of Health · US

Funding

NHGRI/DIR Microarray CoreZICHG200365 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ELKAHLOUN, ABDEL · 2011 to 2025
$9.0M
Intramural NIH HHS Z99 HG999999
6 · The paper itself

Abstract

Preclinical experiments and clinical trials demonstrated that angiotensin II AT

Indexed as

AgingAnimalsBenzimidazolesBiphenyl CompoundsCellular SenescenceGlutamic AcidHippocampusNeuronsNeuroprotectionOxidative StressRatsTetrazolesTranscriptomeBenzimidazolesBiphenyl CompoundscandesartanGlutamic AcidTetrazolesAgingAngiotensin receptor blockersGlutamate excitotoxicityp53 neuroprotectionSenescence

Identifiers

PMID31811565
PMCPMC7062590
OpenAlexW2991734336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.