ArticleBehavior genetics2020
The Association Between Somatic Health, Autism Spectrum Disorder, and Autistic Traits.
Article in Behavior genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies.Development and psychopathology · 2021Pooled it
- The association between ADHD and physical health: a co-twin control study.Scientific reports · 2020Trial
- Influence of Eating Behavior and Dietary Patterns on Gut Microbiota Formation in Children with Autism Spectrum Disorder.Nutrients · 2026Article
- Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.Psychiatric genetics · 2026Article
- Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder.BMC medicine · 2026Article
- Pediatric Somatic and Psychiatric Hospital Contacts in Denmark: A National Overview of Risk Factors, Admissions, and Mortality.Acta psychiatrica Scandinavica · 2026Article
- 'American journal of sexuality education · 2024Article
- Autistic Traits and Somatic Symptom Disorders: What Is the Link?Brain sciences · 2024Review
- Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder.Molecular autism · 2023Article
- Alexithymia and intolerance of uncertainty predict somatic symptoms in autistic and non-autistic adults.Autism : the international journal of research and practice · 2023Article
- Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders.Molecular psychiatry · 2023Article
- Guest editorial: Overview, implications, and directions of twin design research exploring neurodevelopmental conditions.JCPP advances · 2022Article
- Meeting the 24-h movement guidelines and health-related outcomes among youth with autism spectrum disorder: a seven-country observational study.Child and adolescent psychiatry and mental health · 2022Article
- Identification of methylation markers for diagnosis of autism spectrum disorder.Metabolic brain disease · 2022Article
- Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45.Autism research : official journal of the International Society for Autism Research · 2021Article
- Behavioral and biological divergence in monozygotic twin pairs discordant for autism phenotypes: A systematic review.JCPP advances · 2021Article
- Rationale of an Advanced Integrative Approach Applied to Autism Spectrum Disorder: Review, Discussion and Proposal.Journal of personalized medicine · 2021Review
- Introduction to the Special Issue on 'The Genetic Architecture of Neurodevelopmental Disorders'.Behavior genetics · 2020Article
- Bridging the Gap Between Physical Health and Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
This study used a twin cohort to investigate the association of autism spectrum disorder (ASD) and autistic traits with somatic health. A total of 344 twins (172 pairs; mean age 15.56 ± 5.62 years) enriched for ASD and other neurodevelopmental conditions were examined. Medical history and current physical problems were collected with a validated questionnaire to determine twin's somatic health. The Social Responsiveness Scale (SRS-2) was used to measure the participant's severity of autistic traits. Identified somatic health issues with significant within-twin pair differences were tested in relation to both ASD diagnosis and autistic traits in a co-twin control model. Twins with ASD exhibited more neurological and immunological health problems compared to those without ASD (p = 0.005 and p = 0.004, respectively). The intra-pair differences of neurological conditions and SRS-2 score were significantly correlated in monozygotic twins differing for autism traits (r = 0.40, p = 0.001), while the correlation was not found for immunological problems. In addition, a conditional model for analysis of within-twin pair effects revealed an association between neurological problems and clinical ASD diagnosis (Odds ratio per neurological problem 3.15, p = 0.02), as well as autistic traits (β = 10.44, p = 0.006), after adjusting for possible effects of co-existing attention deficit hyperactivity disorder and general intellectual abilities. Our findings suggest that neurological problems are associated with autism, and that non-shared environmental factors contribute to the overlap for both clinical ASD and autistic traits. Further population-based twin studies are warranted to validate our results and examine in detailed the shared genetic and environmental contributions of neurological problems and ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.