Trial reportLasers in medical science2020
Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study.
Trial report in Lasers in medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Analgesic Efficacy of Low-Level Laser Therapy for Postoperative Endodontic Pain: A Systematic Review and Meta-Analysis.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Pooled it
- Lasers efficacy in pain management after primary and secondary endodontic treatment: a systematic review and meta-analysis of randomized clinical trials.Scientific reports · 2024Pooled it
- Effect of calcium silicate and epoxy resin-based sealers on postoperative pain: a randomized clinical trial.BMC oral health · 2026Trial
- Postoperative pain after emergency pulpectomy with or without photobiomodulation in symptomatic irreversible pulpitis A randomized clinical trial.Scientific reports · 2026Trial
- Clinical study on low-level laser therapy to control postoperative pain and quality of life in patients undergoing root canal treatment.Bioinformation · 2026Article
- Photobiomodulation vs. nonsteroidal anti-inflammatory drugs after diode laser excision of lower lip lesions: a case series.Lasers in medical science · 2025Article
- Protocol for low-level laser therapy (LLLT) to control post-endodontic treatment pain in patients with apical periodontitis: a randomized controlled trial.BMC oral health · 2025Article
- Effectiveness of Irrigation Protocols in Endodontic Therapy: An Umbrella Review.Dentistry journal · 2025Review
- Effect of Laser Photobiomodulation on Postoperative Pain After Single-Visit Endodontic Treatment in Children: A Randomized Control Trial.Children (Basel, Switzerland) · 2024Article
- Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review.Healthcare (Basel, Switzerland) · 2023Review
- Efficacy of Different Ibuprofen Formulations with Two Prescription Methods on Post Endodontic Pain of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial.Iranian endodontic journal · 2022Article
- Postoperative Pain following Root Canal Filling with Bioceramic vs. Traditional Filling Techniques: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2021Review
- Calcium Silicate-Based Sealers Do Not Reduce the Risk and Intensity of Postoperative Pain after Root Canal Treatment when Compared with Epoxy Resin-Based Sealers: A Systematic Review and Meta-Analysis.European journal of dentistry · 2021Article
- Systematic Review on the Role of Lasers in Endodontic Therapy: Valuable Adjunct Treatment?Dentistry journal · 2020Review
- Effect of Low-level Laser Therapy With Different Locations of Irradiation on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double-Blind Randomized Controlled Trial.Journal of lasers in medical sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to compare the effect of Ibuprofen and the application of photobiomodulation therapy protocol on the reduction of postoperative pain in endodontically treated teeth using a randomized clinical trial design. Seventy patients, diagnosed with symptomatic irreversible pulpitis, were selected. Treatment was performed by a single operator; a reciprocal system was used to prepare the canals; they were obturated using the Tagger's hybrid technique and coronally sealed with glass-ionomer cement. After treatment, patients were randomly divided into 2 groups. In the active control group, two Ibuprofen 600 mg tablets were administered within a 12-h interval. In the photobiomodulation therapy group, the irradiation was applied after treatment. The evaluation of postoperative pain was performed by another researcher blinded to the groups at 6, 12, 24, and 72 h intervals after treatment. To measure the outcome, two pain scales were used: numerical rate scale (NRS) and verbal rate scale (VRS). Data were analyzed using the chi-square, Mann-Whitney, and Wilcoxon paired tests. Outcome was superior with photobiomodulation therapy at 6 h (p < 0.001), 12 h (p = 0.005), and 24 h (p < 0.001) intervals compared with Ibuprofen. The results for the 72 h (p = 0.317) interval were similar, both in the VRS and NRS scales. It may be concluded that the use of photobiomodulation therapy was effective in reducing pain within the first 24 h when compared with the administration of Ibuprofen 600 mg.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.