Evidence map›Paper›PMID 31811491›Full record

ReviewMagma (New York, N.Y.)2020

Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei.

Geoffrey J Topping, Christian Hundshammer, Luca Nagel, Martin Grashei, Maximilian Aigner, Jason G Skinner, Rolf F Schulte, Franz Schilling

Abstract readReview
In one paragraph

Review in Magma (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  6. First in-human evaluation of [1-Magnetic resonance in medicine · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. HyperpolarizedBiomedicines · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Geoffrey J ToppingDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Christian HundshammerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Luca NagelDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Martin GrasheiDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Maximilian AignerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jason G SkinnerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Rolf F SchulteGeneral Electric Healthcare, Munich, Germany.
Franz SchillingDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. schilling@tum.de.ORCID http://orcid.org/0000-0001-5239-4628

Funding

Bundesministerium für Bildung und Forschung 13EZ1114Deutsche Forschungsgemeinschaft 391523415Deutsche Forschungsgemeinschaft SFB824H2020 European Research Council 820374
6 · The paper itself

Abstract

Hyperpolarization is an emerging method in magnetic resonance imaging that allows nuclear spin polarization of gases or liquids to be temporarily enhanced by up to five or six orders of magnitude at clinically relevant field strengths and administered at high concentration to a subject at the time of measurement. This transient gain in signal has enabled the non-invasive detection and imaging of gas ventilation and diffusion in the lungs, perfusion in blood vessels and tissues, and metabolic conversion in cells, animals, and patients. The rapid development of this method is based on advances in polarizer technology, the availability of suitable probe isotopes and molecules, improved MRI hardware and pulse sequence development. Acquisition strategies for hyperpolarized nuclei are not yet standardized and are set up individually at most sites depending on the specific requirements of the probe, the object of interest, and the MRI hardware. This review provides a detailed introduction to spatially resolved detection of hyperpolarized nuclei and summarizes novel and previously established acquisition strategies for different key areas of application.

Indexed as

AnimalsGasesHumansImage Processing, Computer-AssistedMagnetic FieldsMagnetic Resonance ImagingPerfusionRadio WavesRatsReproducibility of ResultsSignal Processing, Computer-AssistedVentilationGasesHyperpolarizationMagnetic resonance imaging (MRI)Metabolic imagingSpectroscopic imaging (MRSI)Spectroscopy

Identifiers

PMID31811491
PMCPMC7109201

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.