Evidence map›Paper›PMID 31811490›Full record

ArticleMagma (New York, N.Y.)2020

Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI.

Anita A Harteveld, Anneloes de Boer, Suzanne Lisa Franklin, Tim Leiner, Marijn van Stralen, Clemens Bos

Abstract readComparative Study
In one paragraph

Article in Magma (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  3. Renal MRI: From Nephron to NMR Signal.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study.Journal of magnetic resonance imaging : JMRI · 2021
    Article
  9. HyperpolarizedDiagnostics (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anita A HarteveldDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Postbox 85500, 3508 GA, Utrecht, The Netherlands. a.a.harteveld-2@umcutrecht.nl.ORCID http://orcid.org/0000-0002-3379-0710
Anneloes de BoerDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
Suzanne Lisa FranklinDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
Tim LeinerDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
Marijn van StralenDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
Clemens BosDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Postbox 85500, 3508 GA, Utrecht, The Netherlands.

Funding

Stichting voor de Technische Wetenschappen 14951Universitair Medisch Centrum Utrecht Alexandre Suerman stipend for MD-PhD students
6 · The paper itself

Abstract

objectiveTo compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI.

methodsMulti-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) were calculated for the cortex and medulla in both kidneys. Bland-Altman plots, intra-class correlation coefficient, and within-subject coefficient of variation were used to assess reliability and agreement between measurements.

resultsFor the first visit, RBF was 362 ± 57 and 140 ± 47 mL/min/100 g, and ATT was 0.47 ± 0.13 and 0.70 ± 0.10 s in cortex and medulla, respectively, using FAIR; RBF was 201 ± 72 and 84 ± 27 mL/min/100 g, and ATT was 0.71 ± 0.25 and 0.86 ± 0.12 s in cortex and medulla, respectively, using pCASL. For both labeling approaches, RBF and ATT values were not significantly different between visits. Overall, FAIR showed higher PWS and tSNR. Moreover, repeatability of perfusion parameters was better using FAIR. DISCUSSION: This study showed that compared to (balanced) pCASL, FAIR perfusion values were significantly higher and more comparable between visits.

Indexed as

Magnetic Resonance ImagingSpin LabelsAdultArteriesFemaleGlomerular Filtration RateHealthy VolunteersHumansImage Processing, Computer-AssistedKidneyKidney CortexKidney MedullaMaleMiddle AgedPerfusionProspective StudiesSpin LabelsArterial spin labeling (ASL)Arterial transit timeKidneyMagnetic resonance imagingRenal blood flow

Identifiers

PMID31811490
PMCPMC7021666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.