SynthesisSurgical endoscopy2020
Peritoneal drainage or no drainage after pancreaticoduodenectomy and/or distal pancreatectomy: a meta-analysis and systematic review.
Synthesis in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 7 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Prophylactic abdominal drainage for pancreatic surgery.The Cochrane database of systematic reviews · 2025Pooled it
- Early Drain Removal Versus Routine Drain Removal After Pancreaticoduodenectomy and/or Distal Pancreatectomy: A Meta-Analysis and Systematic Review.Digestive diseases and sciences · 2024Pooled it
- Safety and effectiveness of minimally invasive central pancreatectomy versus open central pancreatectomy: a systematic review and meta-analysis.Surgical endoscopy · 2024Pooled it
- Early vs late drain removal after pancreatic resection-a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- Routine abdominal drainage after distal pancreatectomy: meta-analysis.The British journal of surgery · 2022Pooled it
- Prophylactic abdominal drainage for pancreatic surgery.The Cochrane database of systematic reviews · 2021Pooled it
- Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Prospective cohort study on short-term outcomes of 3D-laparoscopic pancreaticoduodenectomy with stented pancreaticogastrostomy.Surgical endoscopy · 2023Trial
- Surgery-related factors for pancreatic fistula after pancreatectomy: an umbrella review.Hepatobiliary surgery and nutrition · 2025Review
- Pancreatic Fistulas: Current Evidence and Strategy-A Narrative Review.Journal of clinical medicine · 2023Review
- Optimal drain management following complicated laparoscopic cholecystectomy for acute cholecystitis: a propensity-matched comparative study.Journal of minimally invasive surgery · 2022Article
- The Severity of Postoperative Pancreatic Fistula Predicts 30-Day Unplanned Hospital Visit and Readmission after Pancreaticoduodenectomy: A Single-Center Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2022Article
- Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeritoneal drainage has been used routinely after pancreaticoduodenectomy (PD) or distal pancreatectomy (DP). Our objective was to compare patients' outcomes after PD or DP with or without peritoneal drainage.
methodsWe performed a systematic search using the following databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov until 1 June 2019. We included trials comparing no peritoneal drainage versus drainage after PD and/or DP.
resultsTen trials involving 2419 patients were eligible for inclusion. The meta-analysis showed a significantly lower rate of postoperative pancreatic fistula in the no-drain group (odds ratio [OR] 0.39; 95% confidence interval [CI] 0.29-0.51; p < 0.00001). However, there was no significant difference in the analysis of the subgroups, DP and DP + PD peritoneal drainage (p = 0.10, p = 0.19; respectively). The analysis of all studies showed no significant difference between groups regarding clinically related postoperative pancreatic fistula (OR 0.71; 95% CI 0.41-1.24; p = 0.23). Mortality was higher in the drain group in the PD + DP subgroup (OR 0.41; 95% CI 0.27-0.62; p < 0.0001). No significant differences were found regarding intra-abdominal abscess, delayed gastric emptying, biliary fistula, postoperative hemorrhage, or morbidity.
conclusionOur results showed comparable outcomes for PD and DP with or without drainage. However, we can draw no clear conclusions because of the study limitations. Further studies on this topic are recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.