Evidence map›Paper›PMID 31811438›Full record

ArticleDigestive diseases and sciences2020

Radiological Response Is Associated with Better Outcomes and Should Be Considered a Therapeutic Target in Crohn's Disease.

Eléonore Hallé, Mustapha Azahaf, Nicolas Duveau, Thomas Lambin, Maria Nachury, Julien Branche, Romain Gérard, Clémentine Lauriot Dit Prevost, Pauline Wils, Pierre Desreumaux and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Eléonore HalléGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Mustapha AzahafRadiology Department, CHRU Lille, Université Lille, Lille, France.
Nicolas DuveauGastroenterology Department, CHR Roubaix, Roubaix, France.
Thomas LambinGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Maria NachuryGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Julien BrancheGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Romain GérardGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Clémentine Lauriot Dit PrevostGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Pauline WilsGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Pierre DesreumauxGastroenterology Department, CHRU Lille, Université Lille, Lille, France.
Olivier ErnstRadiology Department, CHRU Lille, Université Lille, Lille, France.
Benjamin ParienteGastroenterology Department, CHRU Lille, Université Lille, Lille, France. benjamin.pariente@chru-lille.fr.
Université de Lille · FRCentre Hospitalier de Roubaix · FRInserm · FRLille’s Cardiology Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the study was to identify factors associated with a radiological response and to assess the impact of radiological improvement in long-term outcomes in small bowel (SB) Crohn's disease (CD) patients.

methodsWe performed a retrospective study from June 2011 to June 2017 in the tertiary center, Claude Huriez Hospital in Lille, France. All SB CD patients, who underwent two magnetic resonance enterographies (MRE) 3-12 months apart, with at least 1-year follow-up after the second MRE, were included. Signs of radiological inflammation were identified by two expert radiologists in CD. Patients were classified as radiological responders (RR) and non-responders (NR). Hospitalization rates, adjustment of treatment, and surgical or endoscopic interventions were assessed and compared between RR and NR. Factors associated with a radiological response were also studied using the Cox model.

resultsOne hundred and fifteen SB CD patients were included with a median follow-up of 17 months (IQR 11.6-28.3). There were 54 (47%) RR and 61 (53%) NR. The risk of surgical or endoscopic intervention was higher in NR than RR (p = 0.04), and the median delay until a surgical or endoscopic intervention was shorter in NR (p = 0.04). Multifocal disease, a hypersignal on diffusion-weighted or dynamic contrast-enhanced imaging, a stricture, or a fistula was significantly associated with a decreased probability of a radiological response (p < 0.05).

conclusionThis study shows that a radiological response is associated with a decreased risk of surgical or endoscopic intervention and should be considered as a therapeutic target in CD patients.

Indexed as

Diffusion Magnetic Resonance ImagingWound HealingAdolescentAdultCrohn DiseaseDisease ProgressionFemaleFranceHospitalizationHumansIntestine, SmallMaleMiddle AgedPredictive Value of TestsRemission InductionRetrospective StudiesCrohn’s diseaseDisease complicationsMagnetic resonance enterographyTransmural healing

Identifiers

PMID31811438
OpenAlexW2992367942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.