Evidence map›Paper›PMID 31811430›Full record

ArticleEuropean radiology2020

Increased diagnostic accuracy of giant cell arteritis using three-dimensional fat-saturated contrast-enhanced vessel-wall magnetic resonance imaging at 3 T.

Guillaume Poillon, Adrien Collin, Ygal Benhamou, Gaëlle Clavel, Julien Savatovsky, Cécile Pinson, Kevin Zuber, Frédérique Charbonneau, Catherine Vignal, Hervé Picard and 5 more

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Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Vessel wall MR imaging in neuroradiology.La Radiologia medica · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Guillaume PoillonDepartment of Neuroradiology, Foundation Adolphe de Rothschild Hospital, 29 rue Manin, 75019, Paris, France.
Adrien CollinDepartment of Neuroradiology, Foundation Adolphe de Rothschild Hospital, 29 rue Manin, 75019, Paris, France.
Ygal BenhamouDepartment of Internal Medicine, Rouen University Hospital, Normandie Univ, UNIROUEN, INSERM U1096, Rouen, France.
Gaëlle ClavelDepartment of Internal Medicine, Foundation Adolphe de Rothschild Hospital, Paris, France.
Julien SavatovskyDepartment of Neuroradiology, Foundation Adolphe de Rothschild Hospital, 29 rue Manin, 75019, Paris, France.
Cécile PinsonDepartment of Neuroradiology, Rouen University Hospital, Rouen, France.
Kevin ZuberDepartment of Clinical Research, Foundation Adolphe de Rothschild Hospital, Paris, France.
Frédérique CharbonneauDepartment of Neuroradiology, Foundation Adolphe de Rothschild Hospital, 29 rue Manin, 75019, Paris, France.
Catherine VignalDepartment of Ophthalmology, Foundation Adolphe de Rothschild Hospital, Paris, France.
Hervé PicardDepartment of Internal Medicine, Foundation Adolphe de Rothschild Hospital, Paris, France.
Tifenn LeturcqDepartment of Internal Medicine, Foundation Adolphe de Rothschild Hospital, Paris, France.
Sébastien MirandaDepartment of Internal Medicine, Rouen University Hospital, Normandie Univ, UNIROUEN, INSERM U1096, Rouen, France.
Thomas SenéDepartment of Internal Medicine, Foundation Adolphe de Rothschild Hospital, Paris, France.
Emmanuel GerardinDepartment of Neuroradiology, Rouen University Hospital, Rouen, France.
Augustin LeclerDepartment of Neuroradiology, Foundation Adolphe de Rothschild Hospital, 29 rue Manin, 75019, Paris, France. alecler@for.paris.ORCID http://orcid.org/0000-0001-7869-1815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the diagnostic accuracy of 3D versus 2D contrast-enhanced vessel-wall (CE-VW) MRI of extracranial and intracranial arteries in the diagnosis of GCA.

methodsThis prospective two-center study was approved by a national research ethics board and enrolled participants from December 2014 to October 2017. A protocol including both a 2D and a 3D CE-VW MRI at 3 T was performed in all patients. Two neuroradiologists, blinded to clinical data, individually analyzed separately and in random order 2D and 3D sequences in the axial plane only or with reformatting. The primary judgment criterion was the presence of GCA-related inflammatory changes of extracranial arteries. Secondary judgment criteria included inflammatory changes of intracranial arteries and the presence of artifacts. A McNemar's test was used to compare 2D to 3D CE-VW MRIs.

resultsSeventy-nine participants were included in the study (42 men and 37 women, mean age 75 (± 9.5 years)). Fifty-one had a final diagnosis of GCA. Reformatted 3D CE-VW was significantly more sensitive than axial-only 3D CE-VW or 2D CE-VW when showing inflammatory change of extracranial arteries: 41/51(80%) versus 37/51 (73%) (p = 0.046) and 35/50 (70%) (p = 0.03). Reformatted 3D CE-VW was significantly more specific than 2D CE-VW: 27/27 (100%) versus 22/26 (85%) (p = 0.04). 3D CE-VW showed higher sensitivity than 2D CE-VW when detecting inflammatory changes of intracranial arteries: 10/51(20%) versus 4/50(8%), p = 0.01. Interobserver agreement was excellent for both 2D and 3D CE-VW MRI: κ = 0.84 and 0.82 respectively.

conclusions3D CE-VW MRI supported more accurate diagnoses of GCA than 2D CE-VW. KEY POINTS: • 3D contrast-enhanced vessel-wall magnetic resonance imaging is a high accuracy, non-invasive diagnostic tool used to diagnose giant cell arteritis. • 3D contrast-enhanced vessel-wall imaging is feasible for clinicians to complete within a relatively short time, allowing immediate assessment of extra and intracranial arteries. • 3D contrast-enhanced vessel-wall magnetic resonance imaging might be considered a diagnostic tool when intracranial manifestation of GCA is suspected.

Indexed as

AgedAged, 80 and overContrast MediaFemaleGiant Cell ArteritisHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedOrganometallic CompoundsProspective StudiesSensitivity and SpecificityTemporal ArteriesContrast MediagadobutrolOrganometallic CompoundsDiagnosisGiant cell arteritisMagnetic resonance imagingThree-dimensionalTwo-dimensional

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.