Evidence map›Paper›PMID 31811403›Full record

ArticleJournal of materials science. Materials in medicine2019

Investigating the repair of alveolar bone defects by gelatin methacrylate hydrogels-encapsulated human periodontal ligament stem cells.

Jie Pan, Jiajia Deng, Liming Yu, Yuhui Wang, Weihua Zhang, Xinxin Han, Pedro H C Camargo, Jiale Wang, Yuehua Liu

Open access · greenAbstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Jie PanDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China.
Jiajia DengDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China.
Liming YuDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China.
Yuhui WangDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China.
Weihua ZhangDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China.
Xinxin HanDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China.
Pedro H C CamargoDepartment of Chemistry, University of Helsinki, A.I. Virtasen aukio 1, FI, 00014, Helsinki, Finland.
Jiale WangCollege of Science, Donghua University, Shanghai, 201620, China. jiale.wang@dhu.edu.cn.
Yuehua LiuDepartment of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, PR China. liuyuehua@fudan.edu.cn.ORCID http://orcid.org/0000-0003-3033-8873
Fudan University · CNDonghua University · CNUniversity of Helsinki · FI

Funding

National Natural Science Foundation of China 81470768
6 · The paper itself

Abstract

Although various efforts have been made to develop effective treatments for alveolar bone defect, alveolar regeneration has been emerging as the one with the most potential Herein, we investigated the potential of gelatin methacrylate (GelMA) hydrogels-encapsulated human periodontal ligament stem cells (hPDLSCs) to regenerate alveolar bone. The easy, rapid, and cost-effective nature of GelMA hydrogels makes them a promising mode of stem cell-delivery for clinically relevant alveolar bone regeneration. More importantly, GelMA hydrogels provide an optimal niche for hPDLSCs proliferation, migration and osteogenic differentiation, which are critical for alveolar bone regeneration. In this study, we examined the microstructure of GelMA hydrogels, and identified a highly porous and interconnected network. Compressive test of GelMA hydrogels showed that the stress reached a maximum value of 13.67 ± 0.03 kPa when the strain reached 55%. The maximum values of swelling ratio were 700 ± 47% at the fifth hour. The proliferation rate of hPDLSCs in the GelMA hydrogels resembled that in 2D culture and gradually increased. We established a critical-sized rat model of alveolar bone defects, and applied Micro-CT to assess new bone formation. Compared to the control group, there was substantial bone regeneration in the GelMA + hPDLSCs group at both 4 and 8 weeks after the operation. Histological analysis results were consistent with Micro-CT results. Our study demonstrates that the GelMA hydrogels-encapsulated hPDLSCs have a significant alveolar regenerative potential, and may represent a new strategy for the therapy of alveolar bone defects.

Indexed as

HydrogelsAlveolar Bone LossAnimalsBiocompatible MaterialsBone RegenerationCell ProliferationGelatinHumansMethacrylatesPeriodontal LigamentRatsRats, Sprague-DawleyStem CellsTissue EngineeringTissue ScaffoldsBiocompatible MaterialsGelatinHydrogelsMethacrylates

Identifiers

PMID31811403
OpenAlexW2994121878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.