Evidence map›Paper›PMID 31811339›Full record

Trial reportWorld journal of surgery2020

Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers.

Ahmed Elsaid, Mohammed El-Said, Sameh Emile, Mohamed Youssef, Wael Khafagy, Ayman Elshobaky

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07377708 (A Comparison of Autologous Platelet-Rich Plasma Dressing Versus Saline Dressing in the Management of Pediatric Heel Pad Injuries Due to Motorcycle Wheel-Spoke Trauma), which is not on this map. Cited by 50 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 13 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07377708 nacompletednot on this mapstarted 2024, after this paper: background citation

A Comparison of Autologous Platelet-Rich Plasma Dressing Versus Saline Dressing in the Management of Pediatric Heel Pad Injuries Due to Motorcycle Wheel-Spoke Trauma

TypeinterventionalSponsorServices Institute of Medical Sciences, PakistanRan2024 to 2025Enrolled60ConditionsWheel Spoke Injury, Heel Pad Injuries, Wound HealingArmsAutologous Platelet-Rich Plasma (PRP) Dressing, Normal Saline Dressings
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 13 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Trial
  16. Trial
  17. Translational development of ABCB5Stem cell research & therapy · 2022
    Trial
  18. Review
  19. Review
  20. Platelet-Rich Plasma for Diabetic Foot Ulcers: A Cross-Sectional Appraisal of Overlapping Meta-Analyses.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ahmed ElsaidGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt.
Mohammed El-SaidGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt.
Sameh EmileGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt. sameh200@hotmail.com.
Mohamed YoussefGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt.
Wael KhafagyGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt.
Ayman ElshobakyGeneral Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt.
Mansoura University · EGMansoura University Hospital · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis randomized clinical trial was conducted to assess the role of platelet-rich plasma (PRP) gel as a treatment of clean non-healing diabetic foot ulcer (DFU) in comparison with regular dressing with saline as a control.

methodsPatients with DFU were randomly assigned to one of two equal groups: group I received dressing with PRP gel and group II received regular saline dressing. The main outcomes of the study were percent reduction in the dimensions of the DFU, healing of DFU, and complications at 20 weeks of follow-up.

resultsTwenty-four patients were included to the study. The mean age of patients was 55.2 ± 6.4 years. Only three (25%) patients in group I achieved complete healing versus none of group II patients. In total, 8.3% of group I and 41.6% of group II patients did not show any response to treatment. The percent of reduction in the longitudinal and horizontal dimensions of the DFU was significantly greater in group I than group II (43.2% vs 4.1%) and (42.3% vs 8.2%), respectively. The time required to maximum healing was significantly shorter in group I than group II (6.3 ± 2.1 vs 10.4 ± 1.7 weeks, P < 0.0001).

conclusionThe use of PRP gel as a dressing for chronic DFU resulted in a more significant reduction in the size of the ulcer when compared to regular saline dressing. Also the time to reach the point of maximal possible healing with the least wound dimensions was significantly shorter when using PRP as a dressing protocol.

Indexed as

BandagesAdultAgedDiabetic FootFemaleGelsHumansMaleMiddle AgedPlatelet-Rich PlasmaProspective StudiesSaline SolutionWound HealingGelsSaline Solution

Identifiers

PMID31811339
OpenAlexW2994542391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.