Evidence map›Paper›PMID 31811326›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2020

Selective protection of murine cerebral G

Salvador Castaneda Vega, Veronika Leiss, Roland Piekorz, Carsten Calaminus, Katja Pexa, Marta Vuozzo, Andreas M Schmid, Vasudharani Devanathan, Christian Kesenheimer, Bernd J Pichler and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Protective effects of GαNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  2. Cerebrovascular GMolecular imaging and biology · 2023
    Article
  3. Article
  4. Article
  5. Conquering the host:Frontiers in microbiology · 2022
    Review
  6. Toxins · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Salvador Castaneda VegaWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Medical Center, Tübingen, Germany.
Veronika LeissDepartment of Pharmacology and Experimental Therapy, Institute for Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center for Pharmacogenomics and Drug Research, Eberhard Karls University Tübingen, 72074, Tübingen, Germany.
Roland PiekorzInstitute for Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Carsten CalaminusWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Medical Center, Tübingen, Germany.
Katja PexaInstitute for Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Marta VuozzoWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Medical Center, Tübingen, Germany.
Andreas M SchmidWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Medical Center, Tübingen, Germany.
Vasudharani DevanathanDepartment of Pharmacology and Experimental Therapy, Institute for Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center for Pharmacogenomics and Drug Research, Eberhard Karls University Tübingen, 72074, Tübingen, Germany.
Christian KesenheimerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Medical Center, Tübingen, Germany.
Bernd J PichlerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Medical Center, Tübingen, Germany.
Sandra Beer-HammerDepartment of Pharmacology and Experimental Therapy, Institute for Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center for Pharmacogenomics and Drug Research, Eberhard Karls University Tübingen, 72074, Tübingen, Germany.
Bernd NürnbergDepartment of Pharmacology and Experimental Therapy, Institute for Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center for Pharmacogenomics and Drug Research, Eberhard Karls University Tübingen, 72074, Tübingen, Germany. bernd.nuernberg@uni-tuebingen.de.ORCID 0000-0002-5995-6555
Siemens (Germany) · DEUniversity of Tübingen · DEHeinrich Heine University Düsseldorf · DEIndian Institute of Science Education and Research, Tirupati · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pertussis toxin (PTX) is a potent virulence factor in patients suffering from whooping cough, but in its detoxified version, it is applied for vaccination. It is thought to contribute to the pathology of the disease including various CNS malfunctions. Based on its enzymatic activity, PTX disrupts GPCR-dependent signaling by modifying the α-subunit of heterotrimeric G

Indexed as

NeuroprotectionAnimalsBlood-Brain BarrierCapillary PermeabilityCell MembraneFemaleGTP-Binding Protein alpha Subunits, Gi-GoInjectionsIodine RadioisotopesIslets of LangerhansMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLNeuronsPertussis ToxinGNAO1 protein, mouseGTP-Binding Protein alpha Subunits, Gi-GoIodine-124Iodine RadioisotopesPertussis ToxinBiodistributionBlood-brain barrierCNSG-proteinsPertussis toxin/PTX

Identifiers

PMID31811326
OpenAlexW2994473578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.