Evidence map›Paper›PMID 31811279›Full record

ReviewNature reviews. Gastroenterology & hepatology2020

Microbiota in pancreatic health and disease: the next frontier in microbiome research.

Ryan M Thomas, Christian Jobin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ryan M ThomasDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-9251-5543
Christian JobinDepartment of Medicine, Division of Gastroenterology, University of Florida College of Medicine, Gainesville, FL, USA. Christian.jobin@medicine.ufl.edu.

Funding

The role of klebsiella pneumonia-derived colibactin in colitis-associated colon cancerR01DK073338 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2007 to 2023
$5.4M
Impact of microbiota-mediated biotransformation of black tea polyphenolsR01AT008623 · NCCIH · UNIVERSITY OF FLORIDA · PI JOBIN, CHRISTIAN, SANG, SHENGMIN · 2015 to 2019
$2.1M
NCCIH NIH HHS R01 AT008623NIDDK NIH HHS R01 DK073338
6 · The paper itself

Abstract

Diseases intrinsic to the pancreas such as pancreatitis, pancreatic cancer and type 1 diabetes mellitus impart substantial health and financial burdens on society but identification of novel mechanisms contributing to these pathologies are slow to emerge. A novel area of research suggests that pancreatic-specific disorders might be modulated by the gut microbiota, either through a local (direct pancreatic influence) or in a remote (nonpancreatic) fashion. In this Perspectives, we examine literature implicating microorganisms in diseases of the pancreas, specifically pancreatitis, type 1 diabetes mellitus and pancreatic ductal adenocarcinoma. We also discuss evidence of an inherent pancreatic microbiota and the influence of the intestinal microbiota as it relates to disease association and development. In doing so, we address pitfalls in the current literature and areas of investigation that are needed to advance a developing field of research that has clinical potential to reduce the societal burden of pancreatic diseases.

Indexed as

Bacterial TranslocationCarcinoma, Pancreatic DuctalDiabetes Mellitus, Type 1Gastrointestinal MicrobiomeHumansMicrobiotaPancreasPancreatic NeoplasmsPancreatitisToll-Like Receptor 2Toll-Like Receptor 4Toll-Like Receptor 2Toll-Like Receptor 4

Identifiers

PMID31811279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.