ArticleScientific reports2019
Association of multiple glycemic parameters at intensive care unit admission with mortality and clinical outcomes in critically ill patients.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Role of systemic corticosteroids in ventilated patients with chronic obstructive pulmonary disease exacerbation: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Predictive performance of stress hyperglycemia ratio for poor prognosis in critically ill patients: a systematic review and dose-response meta-analysis.European journal of medical research · 2025Pooled it
- Trial
- Continuous imputation of blood gas and metabolic panel laboratory values in the intensive care unit using machine learning.Journal of clinical monitoring and computing · 2026Article
- Under- and overdosing insulin in the hospital: A retrospective cohort study of dose deviation and patient outcomes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Bloodstream Infection After Major Burn Surgery in Relation to Preoperative Glycemic Gap Among Patients Without Diabetes: A Retrospective Cohort Study.International journal of molecular sciences · 2026Article
- Association of inhalation injury with ventilator-associated pneumonia and clinical outcomes in critically ill patients with burns: A retrospective study.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026Article
- Association between stress hyperglycemia ratio and all-cause mortality in patients with acute kidney injury: a retrospective analysis of the MIMIC-IV database using machine learning.BMC nephrology · 2025Article
- Association between SHR and mortality in critically ill patients with CVD: a retrospective analysis and machine learning approach.Diabetology & metabolic syndrome · 2025Article
- Response to the letter to the editor: Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study.Archives of endocrinology and metabolism · 2025Article
- Elevated stress hyperglycemia ratio associated with higher hospital mortality in patients with respiratory failure.Scientific reports · 2025Article
- Nurse-led insulin protocol efficacy for control of hyperglycemia in critically Ill patients.BMC nursing · 2025Article
- Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study.Archives of endocrinology and metabolism · 2025Article
- Association and predictive ability between significant perioperative cardiovascular adverse events and stress glucose rise in patients undergoing non-cardiac surgery.Cardiovascular diabetology · 2024Article
- Between blood glucose and mortality in critically ill patients: Retrospective analysis of the MIMIC-IV database.Journal of diabetes investigation · 2024Article
- Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction.Journal of geriatric cardiology : JGC · 2024Article
- Observational
- Diabetes associates with mortality in critically ill patients with SARS-CoV-2 pneumonia: No diabetes paradox in COVID-19.Heliyon · 2023Article
- Predictive value of glycemic gap and stress glycemia ratio among critically ill patients with acute kidney injury: a retrospective analysis of the MIMIC-III database.BMC nephrology · 2023Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the association of multiple glycemic parameters at intensive care unit (ICU) admission with outcomes in critically ill patients. Critically ill adults admitted to ICU were included prospectively in the study and followed for 180 days until hospital discharge or death. Patients were assessed for glycemic gap, hypoglycemia, hyperglycemia, glycemic variability, and stress hyperglycemia ratio (SHR). A total of 542 patients were enrolled (30% with preexisting diabetes). Patients with glycemic gap >80 mg/dL had increased need for renal replacement therapy (RRT; 37.7% vs. 23.7%, p = 0.025) and shock incidence (54.7% vs. 37.4%, p = 0.014). Hypoglycemia was associated with increased mortality (54.8% vs. 35.8%, p = 0.004), need for RRT (45.1% vs. 22.3%, p < 0.001), mechanical ventilation (MV; 72.6% vs. 57.5%, p = 0.024), and shock incidence (62.9% vs. 35.8%, p < 0.001). Hyperglycemia increased mortality (44.3% vs. 34.9%, p = 0.031). Glycemic variability >40 mg/dL was associated with increased need for RRT (28.3% vs. 14.4%, p = 0.002) and shock incidence (41.4% vs.31.2%, p = 0.039). In this mixed sample of critically ill subjects, including patients with and without preexisting diabetes, glycemic gap, glycemic variability, and SHR were associated with worse outcomes, but not with mortality. Hypoglycemia and hyperglycemia were independently associated with increased mortality.
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