ArticleNature communications2019
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
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- Molecular insights into ligand recognition and signaling of OXGR1.Nature communications · 2025Article
- Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2.Nature communications · 2025Article
- Evaluation of Small-Molecule Binding Site Prediction Methods on Membrane-Embedded Protein Interfaces.Journal of chemical information and modeling · 2025Article
- Unlocking GPCR-ligand interactions: Measuring binding affinities with thermal shift assay.Protein science : a publication of the Protein Society · 2025Article
- Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Impact of Montelukast Duration on the Risk of Neuropsychiatric Disorders in Children with Asthma: A Population-Based Cohort Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Cysteinyl Leukotrienes in Allergic Inflammation.Annual review of pathology · 2025Review
- The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence.Science signaling · 2024Review
- Interaction between α-Synuclein and Bioactive Lipids: Neurodegeneration, Disease Biomarkers and Emerging Therapies.Metabolites · 2024Review
- G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024Article
- DiffBindFR: an SE(3) equivariant network for flexible protein-ligand docking.Chemical science · 2024Article
- Cellular and Molecular Effects of Microgravity on the Immune System: A Focus on Bioactive Lipids.Biomolecules · 2024Review
- Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.Nature communications · 2023Article
- Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.Nature structural & molecular biology · 2022Article
- Structural basis of leukotriene B4 receptor 1 activation.Nature communications · 2022Article
- Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP.Nature protocols · 2022Review
- Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.Biochemical pharmacology · 2021Review
- Molecular basis for lipid recognition by the prostaglandin DProceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
24 authors at 7 institutions in 7 countries.
Anastasiia GusachResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.ORCID http://orcid.org/0000-0002-2594-8573
Aleksandra LugininaResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Egor MarinResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Rebecca L BrouilletteDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.
Élie Besserer-OffroyDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.ORCID http://orcid.org/0000-0002-7473-7043
Jean-Michel LongpréDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.
Andrii IshchenkoBridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, 90089, USA.ORCID http://orcid.org/0000-0002-3797-0604
Petr PopovResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Nilkanth PatelBridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, 90089, USA.
Taku FujimotoOno Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka, 618-8585, Japan.
Toru MaruyamaOno Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka, 618-8585, Japan.
Benjamin StauchBridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, 90089, USA.ORCID http://orcid.org/0000-0001-7626-2021
Margarita ErgashevaResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Daria RomanovskaiaResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.ORCID http://orcid.org/0000-0003-2831-0919
Anastasiia StepkoResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.ORCID http://orcid.org/0000-0003-4603-0371
Kirill KovalevResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Mikhail ShevtsovResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Valentin GordeliyResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.
Gye Won HanBridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, 90089, USA.
Vsevolod KatritchBridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, 90089, USA.ORCID http://orcid.org/0000-0003-3883-4505
Valentin BorshchevskiyResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701.ORCID http://orcid.org/0000-0003-4398-9712
Philippe SarretDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada. Philippe.Sarret@USherbrooke.ca.
Alexey MishinResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701. mishinalexej@gmail.com.ORCID http://orcid.org/0000-0003-3759-380X
Vadim CherezovResearch Сenter for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia, 141701. cherezov@usc.edu.ORCID http://orcid.org/0000-0002-5265-3914
Moscow Institute of Physics and Technology · RUUniversity of Southern California · USUniversité de Sherbrooke · CACentre National de la Recherche Scientifique · FROno Pharmaceutical (Japan) · JPAustrian Academy of Sciences · ATSkolkovo Institute of Science and Technology · RU
Funding
Structural Biology Of G Protein-Coupled ReceptorsR35GM127086 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Vadim Cherezov · 2018 to 2026
$3.6MNIGMS NIH HHS R35 GM127086
Abstract
Cysteinyl leukotriene G protein-coupled receptors CysLT
Indexed as
MutationAnimalsAsthmaComputer SimulationCrystallography, X-RayHEK293 CellsHumansLeukotriene D4LigandsModels, MolecularMolecular Docking SimulationMutagenesisProtein ConformationProtein EngineeringReceptors, LeukotrieneSf9 Cellscysteinyl leukotriene receptor 2Leukotriene D4leukotriene D4 receptorLigandsReceptors, Leukotriene
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