Evidence map›Paper›PMID 31811120›Full record

ArticleNature communications2019

Challenging immunodominance of influenza-specific CD8

C E van de Sandt, E B Clemens, E J Grant, L C Rowntree, S Sant, H Halim, J Crowe, A C Cheng, T C Kotsimbos, M Richards and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Inverted HA-EV immunization elicits stalk-specific influenza immunity and cross-protection in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. CD8Nature communications · 2024
    Article
  12. Article
  13. Increasing HbA1c is associated with reduced CD8Cellular and molecular life sciences : CMLS · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 5 countries.

C E van de SandtDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0002-4155-7433
E B ClemensDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
E J GrantDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
L C RowntreeDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
S SantDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
H HalimInfection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
J CroweDeepdene Surgery, Deepdene, VIC, 3103, Australia.
A C ChengSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
T C KotsimbosDepartment of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, 3004, Australia.
M RichardsVictorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3050, Australia.
A MillerIndigenous Research Network, Griffith University, Brisbane, QLD, 4222, Australia.
S Y C TongVictorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3050, Australia.
J RossjohnInfection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.ORCID http://orcid.org/0000-0002-2020-7522
T H O NguyenDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia.
S GrasInfection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.
W ChenDepartment of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-5221-9771
K KedzierskaDepartment of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute, Melbourne, VIC, 3000, Australia. kkedz@unimelb.edu.au.ORCID http://orcid.org/0000-0001-6141-335X
The University of Melbourne · AUAustralian Research Council · AUThe Royal Melbourne Hospital · AUAlfred Health · AUAustralian Regenerative Medicine Institute · AUGriffith University · AULa Trobe University · AUThe Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8

Indexed as

Antigen PresentationAntigens, ViralCD8-Positive T-LymphocytesCell LineCross ProtectionCross ReactionsEpitopes, T-LymphocyteHLA-A AntigensHumansImmunologic MemoryInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanModels, MolecularNucleoproteinsOrthomyxoviridaeAntigens, ViralEpitopes, T-LymphocyteHLA-A*68 antigenHLA-A AntigensNucleoproteinsPeptide FragmentsReceptors, Antigen, T-Cell, alpha-betaViral Core Proteins

Identifiers

PMID31811120
PMCPMC6898063
OpenAlexW2993344510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.