ArticleNature communications2019
Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
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- Out of the Niche: A Bird's-Eye View of the Molecular Networks Controlling Root Stem Cells.Plants (Basel, Switzerland) · 2025Review
- Recruitment, rewiring and deep conservation in flowering plant gene regulation.Nature plants · 2025Article
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- The pipelines of deep learning-based plant image processing.Quantitative plant biology · 2025Review
- Machine Learning Inference of Gene Regulatory Networks in DevelopingPlants (Basel, Switzerland) · 2024Article
- Rewiring gene circuitry for plant improvement.Nature genetics · 2024Review
- Changes in cell wall composition due to a pectin biosynthesis enzyme GAUT10 impact root growth.Plant physiology · 2023Article
- The class VIII myosin ATM1 is required for root apical meristem function.Development (Cambridge, England) · 2023Article
- Network Biology Analyses and Dynamic Modeling of Gene Regulatory Networks under Drought Stress Reveal Major Transcriptional Regulators inInternational journal of molecular sciences · 2023Article
- Cell Cycle Dynamics during Stomatal Development: Window of MUTE Action and Ramification of Its Loss-of-Function on an Uncommitted Precursor.Plant & cell physiology · 2023Article
- A Practical Guide to Inferring Multi-Omics Networks in Plant Systems.Methods in molecular biology (Clifton, N.J.) · 2023Article
- POPEYE intercellular localization mediates cell-specific iron deficiency responses.Plant physiology · 2022Article
- Integrative omics approaches for biosynthetic pathway discovery in plants.Natural product reports · 2022Review
- BRAVO self-confined expression through WOX5 in the Arabidopsis root stem-cell niche.Development (Cambridge, England) · 2022Article
- A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants.Developmental cell · 2022Article
- Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets.Science advances · 2022Article
- Gene regulatory networks for compatible versus incompatible grafts identify a role for SlWOX4 during junction formation.The Plant cell · 2022Article
- Comparative Analysis of Seed Transcriptome and Coexpression Analysis Reveal Candidate Genes for Enhancing Seed Size/Weight inFrontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet, how genes expressed across different stem cell types, referred to here as stem-cell-ubiquitous genes, contribute to stem cell regulation is less understood. Here, we find that, in the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks. Development of a mathematical model of TCX2 expression allows us to show that TCX2 orchestrates the coordinated division of different stem cell types. Our results highlight that genes expressed across different stem cell types ensure cross-communication among cells, allowing them to divide and develop harmonically together.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.