Evidence map›Paper›PMID 31810980›Full record

ArticleG3 (Bethesda, Md.)2020

Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages.

William J Janssen, Thomas Danhorn, Chelsea Harris, Kara J Mould, Frank Fang-Yao Lee, Brenna R Hedin, Angelo D'Alessandro, Sonia M Leach, Scott Alper

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. A novelFrontiers in cellular neuroscience · 2024
    Article
  8. Article
  9. Article
  10. American journal of respiratory cell and molecular biology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Metabolic reprogramming of pulmonary fibrosis.Frontiers in pharmacology · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

William J JanssenDepartment of Medicine.
Thomas DanhornCenter for Genes, Environment and Health, and.
Chelsea HarrisCenter for Genes, Environment and Health, and.
Kara J MouldDepartment of Medicine.
Frank Fang-Yao LeeCenter for Genes, Environment and Health, and.
Brenna R HedinCenter for Genes, Environment and Health, and.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, 80045.
Sonia M LeachCenter for Genes, Environment and Health, and.
Scott AlperCenter for Genes, Environment and Health, and alpers@njhealth.org.
National Jewish Health · USUniversity of Colorado Denver · USPulmonary and Critical Care Associates · US

Funding

Lung Macrophage Programming in Acute Lung InjuryR35HL140039 · NHLBI · NATIONAL JEWISH HEALTH · PI JANSSEN, WILLIAM · 2018 to 2024
$6.4M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
Temporal regulation of pulmonary inflammation by MyD88 alternative pre-mRNA splicingR01HL148335 · NHLBI · NATIONAL JEWISH HEALTH · PI ALPER, SCOTT · 2019 to 2022
$2.3M
Reparative functions of human airspace macrophage subsetsR01HL168278 · NHLBI · NATIONAL JEWISH HEALTH · PI Kara J Mould · 2024 to 2026
$1.8M
Toxin-induced alternative mRNA splicing in Toll-like receptor signaling pathwaysR01ES025161 · NIEHS · NATIONAL JEWISH HEALTH · PI ALPER, SCOTT · 2016 to 2020
$1.8M
Metabolic Reprogramming of Recruited Alveolar Macrophages by Arginine In Acute Lung InjuryK08HL141648 · NHLBI · NATIONAL JEWISH HEALTH · PI MOULD, KARA J · 2018 to 2022
$798k
Regulation of innate immunity by a novel protein interaction networkR21AI132827 · NIAID · NATIONAL JEWISH HEALTH · PI ALPER, SCOTT · 2019 to 2020
$450k
NHLBI NIH HHS K08 HL141648NHLBI NIH HHS R01 HL130938NHLBI NIH HHS R01 HL148335NHLBI NIH HHS R01 HL168278NHLBI NIH HHS R35 HL140039NIAID NIH HHS R21 AI132827NIEHS NIH HHS R01 ES025161
6 · The paper itself

Abstract

Alveolar macrophages serve as central orchestrators of inflammatory responses in the lungs, both initiating their onset and promoting their resolution. However, the mechanisms that program macrophages for these dynamic responses are not fully understood. Over 95% of all mammalian genes undergo alternative pre-mRNA splicing. While alternative splicing has been shown to regulate inflammatory responses in macrophages

Indexed as

RNA PrecursorsRNA SplicingAnimalsCytokinesInflammationLipopolysaccharidesMacrophages, AlveolarMetabolic Networks and PathwaysMice, Inbred C57BLRNA-SeqCytokinesLipopolysaccharidesRNA Precursorsalternative pre-mRNA splicingalveolar macrophageglycolysislipopolysaccharidetricarboxylic acid cycle

Identifiers

PMID31810980
PMCPMC7003074
OpenAlexW2991870182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.