ArticleImmunity2019
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1
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Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 476 papers.
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476citing papers in PubMed
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Who cites it
476 citing papers in PubMed.
- An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer.Oncoimmunology · 2026Article
- In Vitro Inhibition of STAT5 Signaling Limits CD8+ T-cell Exhaustion and Improves Outcomes in Adoptive T-cell Therapy.Cancer immunology research · 2026Article
- Targeting the CD4Molecular biomedicine · 2026Article
- ANKRD11 deficiency reprograms CD8Nature immunology · 2026Article
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- Beyond B cell helpers: diverse roles of peripheral helper T cells.International immunology · 2026Review
- Integrative analysis of single-cell sequencing identifies CD8Translational cancer research · 2026Article
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- PD-1 regulates CD4Nature communications · 2026Article
- d-serine as a metabolic immune checkpoint in the tumour microenvironment.EBioMedicine · 2026Article
- Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment.Immunology and cell biology · 2026Review
- The Role of the T Cell Receptor Sequence in Shaping T Cell Functional Fate.Immunological reviews · 2026Review
- GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease.JCI insight · 2026Article
- Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T-cell responses during chronic viral infection.Journal of virology · 2026Article
- The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells.Research square · 2026Article
- Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications.NPJ precision oncology · 2026Review
- T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker.Seminars in immunopathology · 2026Review
- ATF7ip Inhibits the Tumor Immune Response by Promoting Terminal CD8+ T-cell Exhaustion.Cancer immunology research · 2026Article
- Tobemstomig, a Novel Bispecific Antibody, Preferentially Blocks PD-1 and LAG-3 on CD8 TILs to Expand Stem-like T Cells for Sustained Tumor Control.Cancer research communications · 2026Article
416 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byCD42019
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Authors and funding
13 authors.
William H HudsonEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Julia GensheimerEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Masao HashimotoEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Andreas WielandEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Rajesh M ValanparambilEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Peng LiLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.
Jian-Xin LinLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.
Bogumila T KoniecznyEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Se Jin ImEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Gordon J FreemanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Warren J LeonardLaboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.
Haydn T KissickDepartment of Urology, Emory University School of Medicine, Atlanta, GA 30033, USA.
Rafi AhmedEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30033, USA. Electronic address: rahmed@emory.edu.
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MVACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7MSystems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI FREEMAN, GORDON JAMES · 2003 to 2023
$42.5MT CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2MEpigenetic Mechanisms Controlling T-cell Exhaustion in Prostate CancerK99CA197804 · NCI · EMORY UNIVERSITY · PI KISSICK, HAYDN · 2016 to 2017
$223kNCI NIH HHS K99 CA197804NIAID NIH HHS P01 AI056299NIAID NIH HHS R01 AI030048NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI090023NIH HHS P51 OD011132
Abstract
T cell dysfunction is a characteristic feature of chronic viral infection and cancer. Recent studies in chronic lymphocytic choriomeningitis virus (LCMV) infection have defined a PD-1
Indexed as
AnimalsAntigens, CDBiomarkersCD8-Positive T-LymphocytesCX3C Chemokine Receptor 1FemaleGranzymesHepatitis A Virus Cellular Receptor 2Hepatocyte Nuclear Factor 1-alphaLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorAntigens, CDBiomarkersCd101 protein, mouseCX3C Chemokine Receptor 1Cx3cr1 protein, mouseGranzymesGzmb protein, mouseHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Hepatocyte Nuclear Factor 1-alphaHnf1a protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorCD101CD8(+) T cellscheckpoint blockadechronic viral infectionCX3CR1exhaustionimmunotherapyLCMVPD-1T cell differentiation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.