ArticleNeuron2020
Epigenetic Signaling in Glia Controls Presynaptic Homeostatic Plasticity.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The nonfibrillar multiplexin collagen CLE-1 defines cholinergic synapse identity.Science advances · 2025Article
- Transcutaneous electrotherapy of facial nerve injuries based on dissolvable conductive microneedles.Bioactive materials · 2025Article
- Regulation of presynaptic homeostatic plasticity by glial signalling in Alzheimer's disease.The Journal of physiology · 2025Review
- MiR-92 Controls Synaptic Development Through Glial Vha55 Regulation.Biomolecules · 2025Article
- Exact box-counting and temporal sampling algorithms for fractal dimension estimation with applications to animal behavior analysis.Results in engineering · 2025Article
- Genomic Diversity Illuminates the Environmental Adaptation of Drosophila suzukii.Genome biology and evolution · 2024Article
- Dysregulated glial genes in Alzheimer's disease are essential for homeostatic plasticity: Evidence from integrative epigenetic and single cell analyses.Aging cell · 2023Article
- Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Systematic analysis of YFP traps reveals common mRNA/protein discordance in neural tissues.The Journal of cell biology · 2023Article
- Drosophila glia take shape to sculpt the nervous system.Current opinion in neurobiology · 2023Review
- Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity.Frontiers in molecular neuroscience · 2023Article
- Discoidin domain receptor regulates ensheathment, survival and caliber of peripheral axons.Development (Cambridge, England) · 2022Article
- Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity.Neuron · 2022Article
- Alterations of RNA-binding proteinFrontiers in molecular neuroscience · 2022Article
- Distinct molecular pathways govern presynaptic homeostatic plasticity.Cell reports · 2021Article
- Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases.Neural plasticity · 2021Review
- TNF-Mediated Homeostatic Synaptic Plasticity: FromFrontiers in cellular neuroscience · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Epigenetic gene regulation shapes neuronal fate in the embryonic nervous system. Post-embryonically, epigenetic signaling within neurons has been associated with impaired learning, autism, ataxia, and schizophrenia. Epigenetic factors are also enriched in glial cells. However, little is known about epigenetic signaling in glia and nothing is known about the intersection of glial epigenetic signaling and presynaptic homeostatic plasticity. During a screen for genes involved in presynaptic homeostatic synaptic plasticity, we identified an essential role for the histone acetyltransferase and deubiquitinase SAGA complex in peripheral glia. We present evidence that the SAGA complex is necessary for homeostatic plasticity, demonstrating involvement of four new genes in homeostatic plasticity. This is also evidence that glia participate in presynaptic homeostatic plasticity, invoking previously unexplored intercellular, homeostatic signaling at a tripartite synapse. We show, mechanistically, SAGA signaling regulates the composition of and signaling from the extracellular matrix during homeostatic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.