Evidence map›Paper›PMID 31810630›Full record

SynthesisThe Journal of pediatrics2020

Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.

Jian-Rong He, Rema Ramakrishnan, Jane E Hirst, Audrey Bonaventure, Stephen S Francis, Ora Paltiel, Siri E Håberg, Stanley Lemeshow, Sjurdur Olsen, Gabriella Tikellis and 5 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  4. Article
  5. Detection of AdenoviralInternational journal of molecular sciences · 2026
    Article
  6. Exposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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4 · The record

Corrections and comments

  • Commented on by
    2020
5 · Who and what money

Authors and funding

15 authors at 11 institutions in 7 countries.

Jian-Rong HeNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China; The George Institute for Global Health, University of Oxford, Oxford, UK.
Rema RamakrishnanNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK; The George Institute for Global Health, University of Oxford, Oxford, UK; University of New South Wales, Sydney, Australia.
Jane E HirstNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Audrey BonaventureDepartment of Health Sciences, University of York, York, UK; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Stephen S FrancisDivision of Epidemiology, School of Community Health Sciences, University of Nevada, Reno, NV.
Ora PaltielBraun School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Stanley LemeshowDivision of Biostatistics, College of Public Health, Ohio State University, Columbus, OH.
Sjurdur OlsenCenter for Fetal Programming, Department of Epidemiology Research, State Serum Institute, Copenhagen, Denmark.
Gabriella TikellisPopulation Epidemiology, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Michael F G MurphyNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Joseph L WiemelsDepartment of Preventative Medicine, University of Southern California, Los Angeles, CA.
Martha S LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Terence DwyerNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK; The George Institute for Global Health, University of Oxford, Oxford, UK. Electronic address: terence.dwyer@georgeinstitute.ox.ac.uk.
The George Institute for Global Health · GBNorwegian Institute of Public Health · NOUniversity of Oxford · GBHadassah Medical Center · ILLondon School of Hygiene & Tropical Medicine · GBNational Cancer Institute · USRoyal Children's Hospital · AUStatens Serum Institut · DKThe Ohio State University · USUniversity of Nevada, Reno · USUniversity of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

objectiveTo summarize the published evidence regarding the association between maternal infection during pregnancy and childhood leukemia. STUDY

designIn this systematic review and meta-analysis (PROSPERO number, CRD42018087289), we searched PubMed and Embase to identify relevant studies. We included human studies that reported associations of at least one measure of maternal infection during pregnancy with acute lymphoblastic leukemia (ALL) or all childhood leukemias in the offspring. One reviewer extracted the data first using a standardized form, and the second reviewer independently checked the data for accuracy. Two reviewers used the Newcastle-Ottawa Scale to assess the quality of included studies. We conducted random effects meta-analyses to pool the ORs of specific type of infection on ALL and childhood leukemia.

resultsThis review included 20 studies (ALL, n = 15; childhood leukemia, n = 14) reported in 32 articles. Most (>65%) included studies reported a positive association between infection variables and ALL or childhood leukemia. Among specific types of infection, we found that influenza during pregnancy was associated with higher risk of ALL (pooled OR, 3.64; 95% CI, 1.34-9.90) and childhood leukemia (pooled OR, 1.77; 95% CI, 1.01-3.11). Varicella (pooled OR, 10.19; 95% CI, 1.98-52.39) and rubella (pooled OR, 2.79; 95% CI, 1.16-6.71) infections were also associated with higher childhood leukemia risk.

conclusionsOur findings suggest that maternal infection during pregnancy may be associated with a higher risk of childhood leukemia.

Indexed as

ChildFemaleGlobal HealthHumansIncidenceLeukemiaPregnancyPregnancy Complications, InfectiousPrenatal Exposure Delayed EffectsRisk Factorschildhood cancerin uteroPrenatal

Identifiers

PMID31810630
PMCPMC7605597
OpenAlexW2992558031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.