SynthesisThe Journal of pediatrics2020
Cardiometabolic Health and Carotid-Femoral Pulse Wave Velocity in Children: A Systematic Review and Meta-Regression.
Synthesis in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)
Cardiovascular Outcomes and Relative Energy Deficiency in Division I HBCU Athletes: CORE-DI Study
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Brazilian Guidelines for In-office and Out-of-office Blood Pressure Measurement - 2023.Arquivos brasileiros de cardiologia · 2024Guideline
- Hydrocortisone administration in preterm infants is not associated with adverse cardiovascular outcomes in childhood.Pediatric research · 2026Trial
- Inconsistent associations between central and peripheral arterial stiffness indices in relation to age.Quantitative imaging in medicine and surgery · 2026Article
- Cardiovascular disease burden in children with obesity: A narrative review.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- The ambulatory arterial stiffness index is not a measure of arterial stiffness in a selected group of children at risk of secondary hypertension.European journal of pediatrics · 2026Article
- Cardiovascular Assessments in Children and Adolescents With Hypertension.Reviews in cardiovascular medicine · 2025Review
- Association between perceived discrimination and pulse wave velocity: a scoping review.BMJ public health · 2024Article
- Maternal self-reported polycystic ovary syndrome with offspring and maternal cardiometabolic outcomes.Human reproduction (Oxford, England) · 2024Article
- The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome.American journal of physiology. Heart and circulatory physiology · 2023Review
- Blood pressure parameters affecting ventricular repolarization in obese children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Diagnosing Arterial Stiffness in Pregnancy and Its Implications in the Cardio-Renal-Metabolic Chain.Diagnostics (Basel, Switzerland) · 2022Review
- Association of Blood Pressure-Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Association of Parental Socioeconomic Status and Physical Activity with Development of Arterial Stiffness in Prepubertal Children.International journal of environmental research and public health · 2021Article
- Social Jetlag and Cardiometabolic Risk in Preadolescent Children.Frontiers in cardiovascular medicine · 2021Article
- Ambulatory hemodynamic patterns, obesity, and pulse wave velocity in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo identify, in children the normal rate of carotid-femoral pulse wave velocity (cfPWV) progression, and whether presence of cardiometabolic risk factors is associated with cfPWV. STUDY
designElectronic databases (PubMed, Google Scholar) were searched from inception to May 2018, for all studies which reported cfPWV in children (<19 years of age). Random effects meta-regression quantified the association between time (years) and cfPWV, and a systematic review was performed to determine whether cardiometabolic risk factors are associated with cfPWV.
resultsData from 28 articles were eligible for inclusion, including 9 reference value (n = 13 100), 5 cardiovascular risk (n = 5257), 10 metabolic risk (n = 2999), and 8 obesity-focused (n = 8760) studies. Meta-regression findings (9 studies) showed that the increase in cfPWV per year (age) was 0.12 m/second (95% CI, 0.07-0.16 m/second) per year, and when stratified by sex the CIs overlapped. Systematic review findings showed that cardiometabolic risk factors were positively associated with cfPWV, including positive associations with blood pressure, impaired glucose metabolism, and metabolic syndrome. However, obesity was not consistently associated with cfPWV.
conclusionsArterial stiffness in children progresses with age and is associated with cardiometabolic risk factors. Although further longitudinal studies are warranted, the presented reference data will be valuable to epidemiologists tracking children, and to scientists and clinicians prescribing therapies to mitigate risk in a population that is increasingly more vulnerable to cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.