Evidence map›Paper›PMID 31810569›Full record

ArticleAtherosclerosis2020

Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque.

Rajat M Gupta, Peter Libby, Matthias Barton

Abstract readEditorialComment
In one paragraph

Article in Atherosclerosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Effects of Levistilide A on Hemorheology and Endothelial Cell Injury in Rats with Blood Stasis.Evidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Rajat M GuptaDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA. Electronic address: rgupta@bwh.partners.org.
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Matthias BartonMolecular Internal Medicine, University of Zurich, Zürich, Switzerland; Andreas Grüntzig Foundation, Zürich, Switzerland. Electronic address: barton@access.uzh.ch.

Funding

Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
A genetic approach to identify the common mechanisms of vascular diseaseDP2HL152423 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GUPTA, RAJAT M · 2019 to 2022
$2.8M
Novel mechanisms of the thrombotic complications of atherosclerosisR01HL134892 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2019 to 2022
$1.7M
From association to function at the PHACTR1 GWAS locus for coronary atherosclerosisK08HL128810 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GUPTA, RAJAT M · 2016 to 2020
$855k
Single cell analysis of gene expression in human vascular cellsR03HL148483 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GUPTA, RAJAT M · 2019 to 2020
$179k
NHLBI NIH HHS DP2 HL152423NHLBI NIH HHS K08 HL128810NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R03 HL148483
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Endothelin-1Plaque, AtheroscleroticArginaseEndothelium, VascularHumansNitric OxideArginaseEndothelin-1Nitric OxideArginaseCarotid arteryCoronary artery diseaseEndotheliumMacrophagesMyocardial infarctionPlaqueStroke

Identifiers

PMID31810569
PMCPMC7447109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.